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    Influence of antenatal glucocorticoid on preterm lamb diaphragm

    Access Status
    Fulltext not available
    Authors
    Mahzabin, T.
    Pillow, J.
    Pinniger, G.
    Bakker, A.
    Noble, P.
    White, R.
    Karisnan, K.
    Song, Yong
    Date
    2017
    Type
    Journal Article
    
    Metadata
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    Citation
    Mahzabin, T. and Pillow, J. and Pinniger, G. and Bakker, A. and Noble, P. and White, R. and Karisnan, K. et al. 2017. Influence of antenatal glucocorticoid on preterm lamb diaphragm. Pediatric Research. 82 (3): pp. 509-517.
    Source Title
    Pediatric Research
    DOI
    10.1038/pr.2017.99
    ISSN
    0031-3998
    School
    School of Public Health
    URI
    http://hdl.handle.net/20.500.11937/72847
    Collection
    • Curtin Research Publications
    Abstract

    BackgroundPregnant women at a high risk of preterm delivery receive glucocorticoids to accelerate fetal lung maturation and surfactant synthesis. However, the effect of antenatal steroids on the developing diaphragm remains unclear. We hypothesized that maternal betamethasone impairs the fetal diaphragm, and the magnitude of the detrimental effect increases with longer duration of exposure. We aimed to determine how different durations of fetal exposure to maternal betamethasone treatment influence the fetal diaphragm at the functional and molecular levels.MethodsDate-mated merino ewes received intramuscular injections of saline (control) or two doses of betamethasone (5.7 mg) at an interval of 24 h commencing either 2 or 14 days before delivery. Preterm lambs were killed after cesarean delivery at 121-day gestational age. In vitro contractile measurements were performed on the right hemidiaphragm, whereas molecular/cellular analyses used the left costal diaphragm.ResultsDifferent durations of fetal exposure to maternal betamethasone had no consistent effect on the protein metabolic pathway, expression of glucocorticoid receptor and its target genes, cellular oxidative status, or contractile properties of the fetal lamb diaphragm.ConclusionThese data suggest that the potential benefits of betamethasone exposure on preterm respiratory function are not compromised by impaired diaphragm function after low-dose maternal intramuscular glucocorticoid exposure.

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