Synthesis of Benzofuroquinolines via Phosphine-Free Direct Arylation of 4-Phenoxyquinolines in Air

Shanahan, R.; Hickey, A.; Reen, F.; O'Gara, Fergal; McGlacken, G.

doi:10.1002/ejoc.201800923

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Authors

Shanahan, R.

Hickey, A.

Reen, F.

O'Gara, Fergal

McGlacken, G.

Date

2018

Type

Journal Article

Metadata

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Citation

Shanahan, R. and Hickey, A. and Reen, F. and O'Gara, F. and McGlacken, G. 2018. Synthesis of Benzofuroquinolines via Phosphine-Free Direct Arylation of 4-Phenoxyquinolines in Air. European Journal of Organic Chemistry.

Source Title

European Journal of Organic Chemistry

DOI

10.1002/ejoc.201800923

ISSN

1434-193X

School

School of Pharmacy and Biomedical Sciences

URI

http://hdl.handle.net/20.500.11937/72977

Collection

Curtin Research Publications

Abstract

© 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim A palladium-catalysed, phosphine-free, direct arylation of 4-phenoxyquinolines, in air is described. Using an intramolecular approach, the ring-closed products are formed in yields of up to 95 %. This approach allows access to a range of benzofuroquinolines. An array of functional groups on both the quinoline and phenoxy rings are tolerated.