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    Maternal alcohol consumption during pregnancy and its association with offspring renal function at 30 years: observation from a birth cohort study.

    Access Status
    Fulltext not available
    Authors
    Das, S.
    McIntyre, H.
    Alati, Rosa
    Al Mamun, A.
    Date
    2017
    Type
    Journal Article
    
    Metadata
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    Citation
    Das, S. and McIntyre, H. and Alati, R. and Al Mamun, A. 2017. Maternal alcohol consumption during pregnancy and its association with offspring renal function at 30 years: observation from a birth cohort study.. Nephrology.
    Source Title
    Nephrology
    DOI
    10.1111/nep.13206
    ISSN
    1440-1797
    School
    School of Public Health
    URI
    http://hdl.handle.net/20.500.11937/73001
    Collection
    • Curtin Research Publications
    Abstract

    AIM: Prenatal exposure to alcohol has adverse ramifications on foetal development resulting in developmental abnormalities and major congenital anomalies. Experimental studies have documented effects on kidney structure and function among offspring exposed to alcohol during foetal life; however, human evidence is scarce. Thus, the present study aimed to determine the development of CKD among a cohort of 30-year-old Australian offspring whose mothers reported consumption of alcohol during pregnancy. METHODS: The study sample comprised 1626 offspring of the birth the Australia cohort study (MUSP) who serum creatinine was assessed at 30 years old and CKD was categorised from stage 1 to stage 5 based on their level of eGFR following the CKD-EPI definition. RESULTS: Seven percent (n = 111) of offspring had mild to moderate (stage 2 and 3) CKD at 30 years. The overall adjusted odds of CKD were 2.01 (95% CI 0.97 to 4.13) for offspring of moderate to heavy drinking mothers in late pregnancy, 1.60 (0.70 to 3.37) for early pregnancy and 1.18 (0.72 to 1.94) for pre-pregnancy. The association was higher for female offspring-2.69 (1.02 to 7.14) for late pregnancy and 2.95 (1.12 to 7.80) for early pregnancy. Higher but insignificant odds were found for male offspring at late pregnancy 1.44 (0.46 to 4.47) only. CONCLUSION: Maternal alcohol exposure during early and late pregnancy is associated with development of mild to moderate CKD in their offspring at 30 years. This association is stronger for female than male offspring.

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