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Favorable outcome of experimental islet xenotransplantation without immunosuppression in a nonhuman primate model of diabetes

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Authors
Ludwig, B.
Ludwig, S.
Steffen, A.
Knauf, Y.
Zimerman, B.
Heinke, S.
Lehmann, S.
Schubert, U.
Schmid, J.
Bleyer, M.
Schönmann, U.
Colton, C.
Bonifacio, E.
Solimena, Michele
Reichel, A.
Schally, A.
Rotem, A.
Barkai, U.
Grinberg-Rashi, H.
Kaup, F.
Avni, Y.
Jones, P.
Bornstein, S.
Date
2017
Type
Journal Article

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Ludwig, B. and Ludwig, S. and Steffen, A. and Knauf, Y. and Zimerman, B. and Heinke, S. and Lehmann, S. et al. 2017. Favorable outcome of experimental islet xenotransplantation without immunosuppression in a nonhuman primate model of diabetes. Proceedings of the National Academy of Sciences of USA. 114 (44): pp. 11745-11750.
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Proceedings of the National Academy of Sciences of USA
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School of Pharmacy and Biomedical Sciences
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Abstract

© 2017, National Academy of Sciences. All rights reserved. Transplantation of pancreatic islets for treating type 1 diabetes is restricted to patients with critical metabolic lability resulting from the need for immunosuppression and the shortage of donor organs. To overcome these barriers, we developed a strategy to macroencap-sulate islets from different sources that allow their survival and function without immunosuppression. Here we report successful and safe transplantation of porcine islets with a bioartificial pancreas device in diabetic primates without any immune suppression. This strategy should lead to pioneering clinical trials with xenotransplantation for treatment of diabetes and, thereby, represents a previously unidentified approach to efficient cell replacement for a broad spectrum of endocrine disorders and other organ dysfunctions.