Amyloid ß–associated cognitive decline in the absence of clinical disease progression and systemic illness
MetadataShow full item record
© 2017 The Authors Introduction High levels of amyloid ß (Aß) are associated with cognitive decline in cognitively normal (CN) older adults. This study investigated the nature of cognitive decline in healthy individuals who did not progress to mild cognitive impairment or dementia. Method Cognition was measured over 72 months and compared between low (Aß-) and high (Aß+) CN older adults (n = 335) who did not progress to mild cognitive impairment or dementia and who remained free of severe or uncontrolled systemic illness. Results Compared to the Aß- group, the Aß+ group showed no cognitive impairment at baseline but showed substantial decline in verbal learning, episodic memory, and attention over 72 months. Discussion Moderate cognitive decline, particularly for learning and memory, was associated with Aß+ in CN older adults in the absence of clinical disease progression and uncontrolled or serious comorbid illness.
Showing items related by title, author, creator and subject.
Almeida, O.; Garrido, G.; Alfonso, Helman; Hulse, G.; Lautenschlager, N.; Hankey, G.; Flicker, L. (2011)Background: Observational studies investigating the association between smoking, cognitive decline and dementia have produced conflicting results. We completed this trial to determine if smoking cessation decreases the ...
Blood-brain barrier dysfunction precedes cognitive decline and neurodegeneration in diabetic insulin resistant mouse model: An implication for causal linkTakechi, Ryu; Lam, Virginie; Brook, Emily; Giles, Corey; Fimognari, Nicholas; Mooranian, Armin; Al-Salami, Hani; Coulson, Stephanie; Nesbit, Michael; Mamo, John (2017)© 2017 Takechi, Lam, Brook, Giles, Fimognari, Mooranian, Al-Salami, Coulson, Nesbit and Mamo. Diabetic insulin resistance and pro-diabetic diet are reported to increase dementia risk through unknown mechanisms. Emerging ...
Brain and mood changes over 2 years in healthy controls and adults with heart failure and ischaemic heart diseaseAlmeida, O.; Garrido, G.; Etherton-Beer, C.; Lautenschlager, N.; Arnolda, L.; Alfonso, Helman; Flicker, L. (2013)Aims: Heart failure (HF) has been associated with cognitive dysfunction, a high prevalence of mood disorders, and a relative loss of grey matter in several brain regions. This study aimed to determine if, compared with ...