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    Visualization and Modeling of the In Vivo Distribution of Mesenchymal Stem Cells

    Access Status
    Fulltext not available
    Authors
    Wang, H.
    Thorling, C.
    Xu, Z.
    Crawford, D.
    Liang, X.
    Liu, Jian
    Roberts, M.
    Date
    2017
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Wang, H. and Thorling, C. and Xu, Z. and Crawford, D. and Liang, X. and Liu, J. and Roberts, M. 2017. Visualization and Modeling of the In Vivo Distribution of Mesenchymal Stem Cells. Current protocols in stem cell biology. 43: pp. 2B.8.1-2B.8.17.
    Source Title
    Current protocols in stem cell biology
    DOI
    10.1002/cpsc.39
    ISSN
    1938-8969
    School
    WASM: Minerals, Energy and Chemical Engineering (WASM-MECE)
    URI
    http://hdl.handle.net/20.500.11937/73114
    Collection
    • Curtin Research Publications
    Abstract

    Copyright © 2017 John Wiley & Sons, Inc. This unit describes a protocol for elucidating the in vivo disposition of administered mesenchymal stem cells (MSCs). Specifically, direct visualization of donor cell spatiotemporal distribution and assessment of donor cell quantity in recipient organs are described. Protocols for data analysis are suggested, with the goal of developing a model to characterize and predict the physiological kinetics of administered MSCs. The use of this model is described, suggesting that it can be applied to abnormal conditions and has potential interspecies and inter-route predictive capability. These universal methods can be employed, regardless of the type of stem cell or disease, to guide future experiments and design treatment protocols. © 2017 by John Wiley & Sons, Inc.

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