Maternal Prenatal Thyroid Function and Offspring ADHD: Findings from the ALSPAC Cohort
MetadataShow full item record
© Wolters Kluwer Health, Inc. All rights reserved. Thyroid hormone plays a pivotal role in the developing brain and may affect the development of attention deficit hyperactivity disorder (ADHD). This study aimed to examine the role of maternal thyroid function during pregnancy on offspring ADHD. A total of 2912 mother-child pairs were included from the Avon Longitudinal Study of Parents and Children. Thyroid parameters were assessed during the first trimester of pregnancy. Offspring ADHD was assessed using the Development and Well-Being Assessment at the ages of 7.5 and 15 years. The odds of presenting with ADHD were estimated using generalized estimating equations. Levels of thyroid-stimulating hormone (odds ratio [OR], 0.92; 95% confidence interval [CI], 0.48-1.75), free thyroxine (OR, 1.07; 95% CI, 0.87-1.32), and thyroid peroxidase antibodies (OR, 1.00; 95% CI, 0.80-1.25) were not associated with ADHD in children aged 7.5 and 15 years. This study showed no association between maternal thyroid function and offspring ADHD.
Showing items related by title, author, creator and subject.
Mechanisms in endocrinology maternal thyroid dysfunction during pregnancy and behavioural and psychiatric disorders of children: A systematic reviewFetene, D.; Betts, K.; Alati, Rosa (2017)© 2017 European Society of Endocrinology. Background: Maternal thyroid dysfunction during pregnancy may lead to persistent neurodevelopmental disorders in the offspring appearing in later life. This study aimed to review ...
The role of maternal prenatal thyroid function on offspring depression: Findings from the ALSPAC cohortFetene, D.; Betts, K.; Alati, Rosa (2019)© Cambridge University Press 2019. Maternal thyroid dysfunction during pregnancy may contribute to offspring neurobehavioral disorders. In this paper, we investigate the relationship between maternal thyroid function ...
Pre-eclampsia and the risk of attention-deficit/hyperactivity disorder in offspring: Findings from the ALSPAC birth cohort studyDachew, B.; Scott, J.; Mamun, A.; Alati, Rosa (2019)Attention-deficit/hyperactivity disorder (ADHD) is a prevalent heterogeneous neurodevelopmental syndrome associated with various environmental factors. This study examined the association between maternal pre-eclampsia ...