Curtin University Homepage
  • Library
  • Help
    • Admin

    espace - Curtin’s institutional repository

    JavaScript is disabled for your browser. Some features of this site may not work without it.
    View Item 
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item

    Risk factors for Plasmodium falciparum and Plasmodium vivax gametocyte carriage in Papua New Guinean children with uncomplicated malaria

    Access Status
    Fulltext not available
    Authors
    Karl, S.
    Laman, M.
    Moore, Brioni
    Benjamin, J.
    Salib, M.
    Lorry, L.
    Maripal, S.
    Siba, P.
    Robinson, L.
    Mueller, I.
    Davis, T.
    Date
    2016
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Karl, S. and Laman, M. and Moore, B. and Benjamin, J. and Salib, M. and Lorry, L. and Maripal, S. et al. 2016. Risk factors for Plasmodium falciparum and Plasmodium vivax gametocyte carriage in Papua New Guinean children with uncomplicated malaria. Acta Tropica. 160: pp. 1-8.
    Source Title
    Acta Tropica
    DOI
    10.1016/j.actatropica.2016.04.002
    ISSN
    0001-706X
    School
    School of Pharmacy
    URI
    http://hdl.handle.net/20.500.11937/7314
    Collection
    • Curtin Research Publications
    Abstract

    © 2016.There are limited data on gametocytaemia risk factors before/after treatment with artemisinin combination therapy in children from areas with transmission of multiple Plasmodium species. We utilised data from a randomised trial comparing artemether-lumefantrine (AL) and artemisinin-naphthoquine (AN) in 230 Papua New Guinean children aged 0.5-5 years with uncomplicated malaria in whom determinants of gametocytaemia by light microscopy were assessed at baseline using logistic regression and during follow-up using multilevel mixed effects modelling. Seventy-four (32%) and 18 (8%) children presented with P. falciparum and P. vivax gametocytaemia, respectively. Baseline P. falciparum gametocytaemia was associated with Hackett spleen grade 1 (odds ratio (95% CI) 4.01 (1.60-10.05) vs grade 0; P < 0.001) and haemoglobin (0.95 (0.92-0.97) per 1 g/L increase; P < 0.001), and P. falciparum asexual parasitaemia in slide-positive cases (0.36 (0.19-0.68) for a 10-fold increase; P = 0.002). Baseline P. vivax gametocytaemia was associated with Hackett grade 2 (12.66 (1.31-122.56); P = 0.028), mixed P. falciparum/vivax infection (0.16 (0.03-1.00); P = 0.050), P. vivax asexual parasitaemia (5.68 (0.98-33.04); P = 0.053) and haemoglobin (0.94 (0.88-1.00); P = 0.056). For post-treatment P. falciparum gametocytaemia, independent predictors were AN vs AL treatment (4.09 (1.43-11.65)), haemoglobin (0.95 (0.93-0.97)), presence/absence of P. falciparum asexual forms (3.40 (1.66-0.68)) and day post-treatment (0.086 (0.82-0.90)) (P < 0.001). Post-treatment P. vivax gametocytaemia was predicted by presence of P. vivax asexual forms (596 (12-28,433); P < 0.001). Consistent with slow P. falciparum gametocyte maturation, low haemoglobin, low asexual parasite density and higher spleen grading, markers of increased prior infection exposure/immunity, were strong associates of pre-treatment gametocyte positivity. The persistent inverse association between P. falciparum gametocytaemia and haemoglobin during follow-up suggests an important role for bone marrow modulation of gametocytogenesis. In P. vivax infections, baseline and post-treatment gametocyte carriage was positively related to the acute parasite burden, reflecting the close association between the development of asexual and sexual forms.

    Related items

    Showing items related by title, author, creator and subject.

    • Gametocyte clearance kinetics determined by quantitative magnetic fractionation in Melanesian children with uncomplicated malaria treated with artemisinin combination therapy
      Karl, S.; Laman, M.; Moore, Brioni; Benjamin, J.; Koleala, T.; Ibam, C.; Kasian, B.; Siba, P.; Waltmann, A.; Mueller, I.; Woodward, R.; St Pierre, T.; Davis, T. (2015)
      Copyright © 2015, American Society for Microbiology. All Rights Reserved.Quantitative magnetic fractionation and a published mathematical model were used to characterize between-treatment differences in gametocyte density ...
    • Artemisinin-naphthoquine combination therapy for uncomplicated pediatric malaria: A tolerability, safety, and preliminary efficacy study
      Benjamin, J.; Moore, Brioni; Lee, S.; Senn, M.; Griffin, S.; Lautu, D.; Salman, S.; Siba, P.; Mueller, I.; Davis, T. (2012)
      Artemisinin-naphthoquine (ART-NQ) is a fixed-dose coformulated antimalarial therapy recommended as a single-dose treatment and marketed in Papua New Guinea among other tropical countries. We conducted a tolerability, ...
    • Comparison of three methods for detection of gametocytes in Melanesian children treated for uncomplicated malaria
      Karl, S.; Laman, M.; Koleala, T.; Ibam, C.; Kasian, B.; N'Drewei, N.; Rosanas-Urgell, A.; Moore, Brioni; Waltmann, A.; Koepfli, C.; Siba, P.; Betuela, I.; Woodward, R.; St Pierre, T.; Mueller, I.; Davis, T. (2014)
      Background: Gametocytes are the transmission stages of Plasmodium parasites, the causative agents of malaria. As their density in the human host is typically low, they are often undetected by conventional light microscopy. ...
    Advanced search

    Browse

    Communities & CollectionsIssue DateAuthorTitleSubjectDocument TypeThis CollectionIssue DateAuthorTitleSubjectDocument Type

    My Account

    Admin

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Follow Curtin

    • 
    • 
    • 
    • 
    • 

    CRICOS Provider Code: 00301JABN: 99 143 842 569TEQSA: PRV12158

    Copyright | Disclaimer | Privacy statement | Accessibility

    Curtin would like to pay respect to the Aboriginal and Torres Strait Islander members of our community by acknowledging the traditional owners of the land on which the Perth campus is located, the Whadjuk people of the Nyungar Nation; and on our Kalgoorlie campus, the Wongutha people of the North-Eastern Goldfields.