Curtin University Homepage
  • Library
  • Help
    • Admin

    espace - Curtin’s institutional repository

    JavaScript is disabled for your browser. Some features of this site may not work without it.
    View Item 
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item

    Female reproductive history and risk of type 2 diabetes: A prospective analysis of 126 721 women

    Access Status
    Fulltext not available
    Authors
    Pandeya, N.
    Huxley, Rachel
    Chung, H.
    Dobson, A.
    Kuh, D.
    Hardy, R.
    Cade, J.
    Greenwood, D.
    Giles, G.
    Bruinsma, F.
    Demakakos, P.
    Simonsen, M.
    Adami, H.
    Weiderpass, E.
    Mishra, G.
    Date
    2018
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Pandeya, N. and Huxley, R. and Chung, H. and Dobson, A. and Kuh, D. and Hardy, R. and Cade, J. et al. 2018. Female reproductive history and risk of type 2 diabetes: A prospective analysis of 126 721 women. Diabetes, Obesity and Metabolism. 20 (9): pp. 2103-2112.
    Source Title
    Diabetes, Obesity and Metabolism
    DOI
    10.1111/dom.13336
    ISSN
    1462-8902
    School
    School of Public Health
    URI
    http://hdl.handle.net/20.500.11937/73181
    Collection
    • Curtin Research Publications
    Abstract

    © 2018 John Wiley & Sons Ltd Aim: To examine the prospective associations between aspects of a woman's reproductive history and incident diabetes. Methods: We pooled individual data from 126 721 middle-aged women from eight cohort studies contributing to the International Collaboration for a Life Course Approach to Reproductive Health and Chronic Disease Events (InterLACE). Associations between age at menarche, age at first birth, parity and menopausal status with incident diabetes were examined using generalized linear mixed models, with binomial distribution and robust variance. We stratified by body mass index (BMI) when there was evidence of a statistical interaction with BMI. Results: Over a median follow-up of 9 years, 4073 cases of diabetes were reported. Non-linear associations with diabetes were observed for age at menarche, parity and age at first birth. Compared with menarche at age 13 years, menarche at =10 years was associated with an 18% increased risk of diabetes (relative risk [RR] 1.18, 95% confidence interval [CI] 1.02-1.37) after adjusting for BMI. After stratifying by BMI, the increased risk was only observed in women with a BMI =25 kg/m2. A U-shaped relationship was observed between parity and risk of diabetes. Compared with pre-/peri-menopausal women, women with a hysterectomy/oophorectomy had an increased risk of diabetes (RR 1.17, 95% CI 1.07-1.29). Conclusions: Several markers of a woman's reproductive history appear to be modestly associated with future risk of diabetes. Maintaining a normal weight in adult life may ameliorate any increase in risk conferred by early onset of menarche.

    Related items

    Showing items related by title, author, creator and subject.

    • Women’s reproductive health factors and body adiposity: findings from the UK Biobank
      Peters, S.; Huxley, Rachel; Woodward, M. (2015)
      Objective: To conduct a comprehensive examination of the association between women’s reproductive health factors and measures of body adiposity in a contemporary Western population. Methods: A cross-sectional analysis of ...
    • Age at menarche and risk of type 2 diabetes among African-American and white women in the Atherosclerosis Risk in Communities (ARIC) study
      Dreyfus, J.; Lutsey, P.; Huxley, Rachel; Pankow, J.; Selvin, E.; Fernández-Rhodes, L.; Franceschini, N.; Demerath, E. (2012)
      Aims/hypothesis: We examined race differences in the association between age at menarche and type 2 diabetes before and after adjustment for adiposity. Methods: We analysed baseline and 9-year follow-up data from 8,491 ...
    • Sex-specific relevance of diabetes to occlusive vascular and other mortality: a collaborative meta-analysis of individual data from 980?793 adults from 68 prospective studies
      Gnatiuc, L.; Herrington, W.; Halsey, J.; Tuomilehto, J.; Fang, X.; Kim, H.; De Bacquer, D.; Dobson, A.; Criqui, M.; Jacobs, D.; Leon, D.; Peters, S.; Ueshima, H.; Sherliker, P.; Peto, R.; Collins, R.; Huxley, Rachel; Emberson, J.; Woodward, M.; Lewington, S.; Aoki, N.; Arima, H.; Arnesen, E.; Aromaa, A.; Assmann, G.; Bachman, D.; Baigent, C.; Bartholomew, H.; Benetos, A.; Bengtsson, C.; Bennett, D.; Björkelund, C.; Blackburn, H.; Bonaa, K.; Boyle, E.; Broadhurst, R.; Carstensen, J.; Chambless, L.; Chen, Z.; Chew, S.; Clarke, R.; Cox, C.; Curb, J.; D'Agostino, R.; Date, C.; Davey Smith, G.; De Backer, G.; Dhaliwal, S.; Duan, X.; Ducimetiere, P.; Duffy, S.; Eliassen, H.; Elwood, P.; Empana, J.; Garcia-Palmieri, M.; Gazes, P.; Giles, G.; Gillis, C.; Goldbourt, U.; Gu, D.; Guasch-Ferre, M.; Guize, L.; Haheim, L.; Hart, C.; Hashimoto, S.; Hashimoto, T.; Heng, D.; Hjermann, I.; Ho, S.; Hobbs, M.; Hole, D.; Holme, I.; Horibe, H.; Hozawa, A.; Hu, F.; Hughes, K.; Iida, M.; Imai, K.; Imai, Y.; Iso, H.; Jackson, R.; Jamrozik, K.; Jee, S.; Jensen, G.; Jiang, C.; Johansen, N.; Jorgensen, T.; Jousilahti, P.; Kagaya, M.; Keil, J.; Keller, J.; Kim, I.; Kita, Y.; Kitamura, A.; Kiyohara, Y.; Knekt, P.; Knuiman, M.; Kornitzer, M.; Kromhout, D.; Kronmal, R. (2018)
      © 2018 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license Background: Several studies have shown that diabetes confers a higher relative risk of vascular mortality among ...
    Advanced search

    Browse

    Communities & CollectionsIssue DateAuthorTitleSubjectDocument TypeThis CollectionIssue DateAuthorTitleSubjectDocument Type

    My Account

    Admin

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Follow Curtin

    • 
    • 
    • 
    • 
    • 

    CRICOS Provider Code: 00301JABN: 99 143 842 569TEQSA: PRV12158

    Copyright | Disclaimer | Privacy statement | Accessibility

    Curtin would like to pay respect to the Aboriginal and Torres Strait Islander members of our community by acknowledging the traditional owners of the land on which the Perth campus is located, the Whadjuk people of the Nyungar Nation; and on our Kalgoorlie campus, the Wongutha people of the North-Eastern Goldfields.