Hybrid C<inf>3</inf>N<inf>4</inf>/Fluorine-Doped Tin Oxide Electrode Transfers Hydride for 1,4-NADH Cofactor Regeneration

Abstract

© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. Herein, we report the use of graphitic carbon nitride (C&lt;inf&gt;3&lt;/inf&gt;N&lt;inf&gt;4&lt;/inf&gt;)-modified fluorine-doped tin oxide electrodes for the electroregeneration of reduced nicotinamide adenine dinucleotide phosphate (NADH). We synthesized and functionalized these hybrid electrodes by using anodic aluminum-oxide-templated C&lt;inf&gt;3&lt;/inf&gt;N&lt;inf&gt;4&lt;/inf&gt; growth. Electrochemical activation of the semiconducting C&lt;inf&gt;3&lt;/inf&gt;N&lt;inf&gt;4&lt;/inf&gt; islands with a rhodium complex permits selective regeneration of biologically active 1,4-NADH cofactor. A ride for the hydride: Graphitic carbon nitride (C&lt;inf&gt;3&lt;/inf&gt;N&lt;inf&gt;4&lt;/inf&gt;)-modified fluorine-doped tin oxide (FTO) electrodes are used for the electroregeneration of reduced nicotinamide adenine dinucleotide phosphate (NADH). These hybrid electrodes are synthesized by using anodic aluminum-oxide-templated C&lt;inf&gt;3&lt;/inf&gt;N&lt;inf&gt;4&lt;/inf&gt; growth. Electrochemical activation of the semiconducting C&lt;inf&gt;3&lt;/inf&gt;N&lt;inf&gt;4&lt;/inf&gt; islands with a rhodium complex permits selective regeneration of biologically active 1,4-NADH cofactor.