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    The Interaction of Insulin with the Insulin Receptor in a Membrane Environment

    Sabapathy T 2018.pdf (3.838Mb)
    Access Status
    Open access
    Authors
    Sabapathy, Thiruvarutchelvan
    Date
    2018
    Supervisor
    Cyril Mamotte
    Type
    Thesis
    Award
    PhD
    
    Metadata
    Show full item record
    Faculty
    Health Sciences
    School
    Pharmacy and Biomedical Sciences
    URI
    http://hdl.handle.net/20.500.11937/73527
    Collection
    • Curtin Theses
    Abstract

    The first event in insulin action is the binding of insulin to insulin-receptors embedded in the cell membrane. This study investigated how plasma membrane cholesterol influences this interaction, as examined in several experimental models including cultured cells, virus-like-particles and liver cell plasma membranes. The study is of relevance to a better understanding of diabetes at a molecular level. Novel results include the demonstration that alterations in membrane cholesterol content significantly reduce insulin binding and signalling.

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