Show simple item record

dc.contributor.authorSabapathy, Thiruvarutchelvan
dc.contributor.supervisorCyril Mamotteen_US

The first event in insulin action is the binding of insulin to insulin-receptors embedded in the cell membrane. This study investigated how plasma membrane cholesterol influences this interaction, as examined in several experimental models including cultured cells, virus-like-particles and liver cell plasma membranes. The study is of relevance to a better understanding of diabetes at a molecular level. Novel results include the demonstration that alterations in membrane cholesterol content significantly reduce insulin binding and signalling.

dc.publisherCurtin Universityen_US
dc.titleThe Interaction of Insulin with the Insulin Receptor in a Membrane Environmenten_US
curtin.departmentPharmacy and Biomedical Sciencesen_US
curtin.accessStatusFulltext not availableen_US
curtin.facultyHealth Sciencesen_US

Files in this item


This item appears in the following Collection(s)

Show simple item record