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dc.contributor.authorSabapathy, Thiruvarutchelvan
dc.contributor.supervisorCyril Mamotteen_US
dc.date.accessioned2018-12-19T00:28:13Z
dc.date.available2018-12-19T00:28:13Z
dc.date.issued2018
dc.identifier.urihttp://hdl.handle.net/20.500.11937/73527
dc.description.abstract

The first event in insulin action is the binding of insulin to insulin-receptors embedded in the cell membrane. This study investigated how plasma membrane cholesterol influences this interaction, as examined in several experimental models including cultured cells, virus-like-particles and liver cell plasma membranes. The study is of relevance to a better understanding of diabetes at a molecular level. Novel results include the demonstration that alterations in membrane cholesterol content significantly reduce insulin binding and signalling.

en_US
dc.publisherCurtin Universityen_US
dc.titleThe Interaction of Insulin with the Insulin Receptor in a Membrane Environmenten_US
dc.typeThesisen_US
dcterms.educationLevelPhDen_US
curtin.departmentPharmacy and Biomedical Sciencesen_US
curtin.accessStatusFulltext not availableen_US
curtin.facultyHealth Sciencesen_US
dc.date.embargoEnd2019-12-14


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