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dc.contributor.authorArooj, Mahira
dc.contributor.supervisorRicardo Manceraen_US

This research aimed to repress target genes by modulating their expression through rewriting of aberrant epigenetic landscapes, including DNA methylation and histone post-translational modifications, utilizing epigenetic repressor domains. The epigenetic repressor domains included KRAB, DNMT3A, UHRF1 and CSD, which were delivered via the epigenetic editing tools ZFs, TALEs and the CRISPR/dCas9 system. Our findings suggest that a combination of multiple epigenetic repressor domains targeting epigenetic marks involved in epigenetic cross-talk significantly repressed target genes.

dc.publisherCurtin Universityen_US
dc.titlePrecision Genome Engineering and Gene Silencing Using CRISPR/dCas9 Systemen_US
curtin.departmentPharmacy and Biomedical Sciencesen_US
curtin.accessStatusOpen accessen_US
curtin.facultyScience and Engineeringen_US

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