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    Evaluation of Novel Resveratrol Conjugate and Nanoparticle Formulations for Enhanced Anticancer Activity

    Yee YJ 2018.pdf (6.813Mb)
    Access Status
    Open access
    Authors
    Yee, Yan Jing
    Date
    2018
    Supervisor
    Yan Chen
    Type
    Thesis
    Award
    PhD
    
    Metadata
    Show full item record
    Faculty
    Health Sciences
    School
    School of Pharmacy and Biomedical Sciences
    Curtin Health Innovation Research Institute
    URI
    http://hdl.handle.net/20.500.11937/73581
    Collection
    • Curtin Theses
    Abstract

    Resveratrol is known to undergo rapid metabolism and degradation in vivo. The aim of this project is to synthesise polymeric resveratrol conjugates for formulation into nanoparticles for enhanced anticancer treatment by decreasing the metabolism and degradation rate of resveratrol in vivo. Conjugated resveratrol nanoparticles were found to suppress tumour growth in vivo in a melanoma mouse model although in vitro data shows lesser anti-proliferative effect than resveratrol alone.

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      Basavaraj, S; Benson, Heather; Brown, David; Chen, Yan (2013)
      Quantification of pegylated drugs in biological matrices is often complex and challenging. This paper describes a sensitive HPLC method with fluorescence detection for the analysis of pegylated resveratrol, resveratrol ...
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      Siddalingappa, B.; Benson, Heather; Brown, D.; Batty, Kevin; Chen, Y. (2015)
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      Basavaraj, S.; Benson, Heather; Cruickshank, C.; Brown, David; Chen, Yan (2011)
      A simple and reliable liquid chromatography/mass spectrometry (LC/MS) method to monitor pegylation of resveratrol is described. The developed LC/MS method can separate and quantify unmodified MeO-PEG-OH, carboxylic acid ...
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