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    Blood-brain barrier disturbances in diabetes-associated dementia: Therapeutic potential for cannabinoids

    Access Status
    Fulltext not available
    Authors
    Brook, E.
    Mamo, John
    Wong, R.
    Al-Salami, Hani
    Falasca, Marco
    Lam, Virginie
    Takechi, Ryu
    Date
    2019
    Type
    Journal Article
    
    Metadata
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    Citation
    Brook, E. and Mamo, J. and Wong, R. and Al-Salami, H. and Falasca, M. and Lam, V. and Takechi, R. 2019. Blood-brain barrier disturbances in diabetes-associated dementia: Therapeutic potential for cannabinoids. Pharmacological Research. 141: pp. 291-297.
    Source Title
    Pharmacological Research
    DOI
    10.1016/j.phrs.2019.01.009
    ISSN
    1043-6618
    School
    School of Public Health
    URI
    http://hdl.handle.net/20.500.11937/73629
    Collection
    • Curtin Research Publications
    Abstract

    © 2019 Elsevier Ltd Type-2 diabetes (T2D) increases the risk of dementia by ˜5-fold, however the mechanisms by which T2D increases dementia risk remain unclear. Evidence suggests that the heightened inflammation and oxidative stress in T2D may lead to disruption of the blood-brain barrier (BBB), which precedes premature cognitive decline. Studies show that vascular-targeted anti-inflammatory treatments protect the BBB by attenuating neuroinflammation, and in some studies attenuate cognitive decline. Yet, this potential pathway is understudied in T2D-associated cognitive impairment. In recent years, therapeutic potential of cannabinoids has gained much interest. The two major cannabinoids, cannabidiol and tetrahydrocannabinol, exert anti-inflammatory and vascular protective effects, however few studies report their potential for reversing BBB dysfunction, particularly in T2D. Therefore, in this review, we summarize the current findings on the role of BBB dysfunction in T2D-associated dementia and consider the potential therapeutic use of cannabinoids as a protectant of cerebrovascular BBB protection.

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