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    Potential application of zerumbone in the prevention and therapy of chronic human diseases

    Access Status
    Fulltext not available
    Authors
    Singh, Y.
    Girisa, S.
    Banik, K.
    Ghosh, S.
    Swathi, P.
    Deka, M.
    Padmavathi, G.
    Kotoky, J.
    Sethi, G.
    Fan, L.
    Mao, X.
    Halim, C.
    Arfuso, Frank
    Kunnumakkara, A.
    Date
    2019
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Singh, Y. and Girisa, S. and Banik, K. and Ghosh, S. and Swathi, P. and Deka, M. and Padmavathi, G. et al. 2019. Potential application of zerumbone in the prevention and therapy of chronic human diseases. Journal of Functional Foods. 53: pp. 248-258.
    Source Title
    Journal of Functional Foods
    DOI
    10.1016/j.jff.2018.12.020
    ISSN
    1756-4646
    School
    School of Pharmacy and Biomedical Sciences
    URI
    http://hdl.handle.net/20.500.11937/73751
    Collection
    • Curtin Research Publications
    Abstract

    © 2018 Elsevier Ltd Several active compounds from ‘Mother Nature’ have been found to be tailor-made therapeutics for the better management of numerous chronic ailments, with fewer adverse side effects. Zerumbone is one such molecule isolated from the rhizomes of Zingiber zerumbet (L.) Smith, a Zingiberaceae plant with significant medicinal values that has been used traditionally for treating stomach ache, ulcers, diabetes, leprosy, asthma, and skin diseases. Zerumbone has been found to be the most important active compound of Z. zerumbet, contributing to its anti-inflammatory, anti-microbial, anti-hypersensitivity, chemopreventive and chemotherapeutic activities. It has been established as a multi-targeted agent with potential to treat chronic diseases such as osteoarthritis, obesity, diabetes, diabetic nephropathy, diabetic retinopathy, chronic gastritis, neuropathic pain, atherosclerosis, inflammation and cancer through modulation of various cellular signaling cascades and antigen presentation pathways. Therefore, the present study focuses on zerumbone, its sources and biological activities against various chronic diseases by summarizing the literature available.

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