A review on liquid chromatography-tandem mass spectrometry methods for rapid quantification of oncology drugs
MetadataShow full item record
In the last decade, the tremendous improvement in the sensitivity and also affordability of liquid chromatography-tandem mass spectrometry (LC-MS/MS) has revolutionized its application in pharmaceutical analysis, resulting in widespread employment of LC-MS/MS in determining pharmaceutical compounds, including anticancer drugs in pharmaceutical research and also industries. Currently, LC-MS/MS has been widely used to quantify small molecule oncology drugs in various biological matrices to support preclinical and clinical pharmacokinetic studies in R&D of oncology drugs. This mini-review article will describe the state-of-the-art LC-MS/MS and its application in rapid quantification of small molecule anticancer drugs. In addition, efforts have also been made in this review to address several key aspects in the development of rapid LC-MS/MS methods, including sample preparation, chromatographic separation, and matrix effect evaluation.
Showing items related by title, author, creator and subject.
Analysis of pharmaceuticals in indirect potable reuse systems using solid-phase extraction and liquid chromatography-tandem mass spectrometryBusetti, Francesco; Linge, Kathryn; Heitz, Anna (2009)A solid-phase extraction (SPE) LC/MS/MS method for 18 commercial drugs in secondary wastewaterand product water from water recycling plants using microfiltration (MF) and reverse osmosis (RO)has been developed, optimised ...
ß-Methylphenylethylamines: Common fragmentation pathways with amphetamines in electrospray ionization collision-induced dissociationBrown, David; Hansson, R.; Oosthuizen, F.; Sumner, N. (2015)β-Methylphenylethylamines are positional isomers of amphetamines and have been discovered in sporting supplements. Although the fragmentation of the β-methylphenylethylamine and N-methyl-β-methylphenylethylamine in gas ...
Application of Solvent Influenced Fluorescence-quenching and Enhancement to Develop a Highly Sensitive HPLC Methodology for Analysis of Resveratrol-PEG ConjugatesBasavaraj, S; Benson, Heather; Brown, David; Chen, Yan (2013)Quantification of pegylated drugs in biological matrices is often complex and challenging. This paper describes a sensitive HPLC method with fluorescence detection for the analysis of pegylated resveratrol, resveratrol ...