Show simple item record

dc.contributor.authorMerigo, L.
dc.contributor.authorPadula, Fabrizio
dc.contributor.authorLatronico, N.
dc.contributor.authorPaltenghi, M.
dc.contributor.authorVisioli, A.
dc.identifier.citationMerigo, L. and Padula, F. and Latronico, N. and Paltenghi, M. and Visioli, A. 2019. Optimized PID control of propofol and remifentanil coadministration for general anesthesia. Communications in Nonlinear Science and Numerical Simulation. 72: pp. 194-212.

© 2018 Elsevier B.V. A closed-loop control system for the control of the depth of hypnosis in anesthesia by using propofol-remifentanil coadministration and the Bispectral Index as feedback signal is proposed. A PID controller is employed together with a fixed ratio between propofol and remifentanil infusions. The ratio allows the anesthesiologist to control the opioid-hypnotic balance during surgery. Optimal tuning rules for the proposed controller are obtained off-line by using the particle swarm optimization method and by considering a given dataset of patients and a wide range of infusion ratios that covers a rich set of scenarios that might occur in clinical practice. Finally, a gain scheduling strategy guarantees the optimality of the performance both for the induction and the maintenance phase. A Monte Carlo approach is used to evaluate the robustness of the method with respect to intra- and inter-patient variability.

dc.titleOptimized PID control of propofol and remifentanil coadministration for general anesthesia
dc.typeJournal Article
dcterms.source.titleCommunications in Nonlinear Science and Numerical Simulation
curtin.departmentSchool of Electrical Engineering, Computing and Mathematical Science (EECMS)
curtin.accessStatusFulltext not available

Files in this item


There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record