Upper Airway Cell Transcriptomics Identify a Major New Immunological Phenotype with Strong Clinical Correlates in Young Children with Acute Wheezing.
dc.contributor.author | Khoo, S. | |
dc.contributor.author | Read, J. | |
dc.contributor.author | Franks, K. | |
dc.contributor.author | Zhang, Guicheng | |
dc.contributor.author | Bizzintino, J. | |
dc.contributor.author | Coleman, L. | |
dc.contributor.author | McCrae, C. | |
dc.contributor.author | Öberg, L. | |
dc.contributor.author | Troy, N. | |
dc.contributor.author | Prastanti, F. | |
dc.contributor.author | Everard, J. | |
dc.contributor.author | Oo, S. | |
dc.contributor.author | Borland, M. | |
dc.contributor.author | Maciewicz, R. | |
dc.contributor.author | Le Souëf, P. | |
dc.contributor.author | Laing, I. | |
dc.contributor.author | Bosco, A. | |
dc.date.accessioned | 2019-02-19T04:16:18Z | |
dc.date.available | 2019-02-19T04:16:18Z | |
dc.date.created | 2019-02-19T03:58:12Z | |
dc.date.issued | 2019 | |
dc.identifier.citation | Khoo, S. and Read, J. and Franks, K. and Zhang, G. and Bizzintino, J. and Coleman, L. and McCrae, C. et al. 2019. Upper Airway Cell Transcriptomics Identify a Major New Immunological Phenotype with Strong Clinical Correlates in Young Children with Acute Wheezing.. J Immunol. | |
dc.identifier.uri | http://hdl.handle.net/20.500.11937/74236 | |
dc.identifier.doi | 10.4049/jimmunol.1800178 | |
dc.description.abstract |
Asthma exacerbations are triggered by rhinovirus infections. We employed a systems biology approach to delineate upper-airway gene network patterns underlying asthma exacerbation phenotypes in children. Cluster analysis unveiled distinct IRF7hi versus IRF7lo molecular phenotypes, the former exhibiting robust upregulation of Th1/type I IFN responses and the latter an alternative signature marked by upregulation of cytokine and growth factor signaling and downregulation of IFN-?. The two phenotypes also produced distinct clinical phenotypes. For IRF7lo children, symptom duration prior to hospital presentation was more than twice as long from initial symptoms (p = 0.011) and nearly three times as long for cough (p < 0.001), the odds ratio of admission to hospital was increased more than 4-fold (p = 0.018), and time to recurrence was shorter (p = 0.015). In summary, our findings demonstrate that asthma exacerbations in children can be divided into IRF7hi versus IRF7lo phenotypes with associated differences in clinical phenotypes. | |
dc.title | Upper Airway Cell Transcriptomics Identify a Major New Immunological Phenotype with Strong Clinical Correlates in Young Children with Acute Wheezing. | |
dc.type | Journal Article | |
dcterms.source.issn | 1550-6606 | |
dcterms.source.title | J Immunol | |
curtin.department | School of Public Health | |
curtin.accessStatus | Fulltext not available |
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