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    Metal-based antitumor compounds: beyond cisplatin

    Access Status
    Fulltext not available
    Authors
    Simpson, Peter
    Desai, N.
    Casari, I.
    Massi, Massimiliano
    Falasca, Marco
    Date
    2019
    Type
    Journal Article
    
    Metadata
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    Citation
    Simpson, P. and Desai, N. and Casari, I. and Massi, M. and Falasca, M. 2019. Metal-based antitumor compounds: beyond cisplatin. Future Medicinal Chemistry. 11 (2): pp. 119-135.
    Source Title
    Future Medicinal Chemistry
    DOI
    10.4155/fmc-2018-0248
    ISSN
    1756-8927
    School
    Nanochemistry Research Institute
    URI
    http://hdl.handle.net/20.500.11937/74389
    Collection
    • Curtin Research Publications
    Abstract

    Despite improvements in the 5-year survival rate to over 80% in cancers, such as Hodgkin lymphoma and testicular cancer, more aggressive tumors including pancreatic and brain cancer still have extremely low survival rates. The establishment of chemoresistance, responsible for the reduction in treatment efficiency and cancer relapse, is one possible explanation for this setback. Metal-based compounds, a class of anticancer drugs, are largely used in the treatment of cancer. Herein, we will review the use of metal-based small molecules in chemotherapy, focusing on recent studies, and we will discuss how new nonplatinum-based agents are prompting scientists to increase drug specificity to overcome chemoresistance in cancer cells.

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