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dc.contributor.authorAl Haydar, Muder
dc.contributor.authorAbid, H.
dc.contributor.authorSunderland, B.
dc.contributor.authorWang, Shaobin
dc.date.accessioned2019-02-19T04:16:54Z
dc.date.available2019-02-19T04:16:54Z
dc.date.created2019-02-19T03:58:32Z
dc.date.issued2019
dc.identifier.citationAl Haydar, M. and Abid, H. and Sunderland, B. and Wang, S. 2019. Multimetal organic frameworks as drug carriers: Aceclofenac as a drug candidate. Drug Design, Development and Therapy. 13: pp. 23-35.
dc.identifier.urihttp://hdl.handle.net/20.500.11937/74417
dc.identifier.doi10.2147/DDDT.S182983
dc.description.abstract

Background: Multimetal organic frameworks (M-MOFs) were synthesized by including a second metal ion with the main base metal in the synthesis process to enhance their applications for drug delivery. Aceclofenac (ACF), a nonsteroidal anti-inflammatory analgesic drug of low aqueous solubility, was selected as a candidate for the drug delivery system Purpose: This study aimed to evaluate the loading capacity (LC) and entrapment efficiency (EE) percentages of multi-Material of Institute Lavoisier (MIL)-100(Fe) (M-MIL-100(Fe)) for ACF. Materials and methods: Hydrothermal synthesis procedure was used to prepare multi-MIL-100(Fe) samples (Zn I-MIL-100(Fe), Zn II-MIL-100(Fe), Ca I-MIL-100(Fe), Ca II-MIL-100-(Fe), Mg I-MIL-100(Fe), Mg II-MIL-100(Fe), Mn I-MIL-100(Fe), and Mn II-MIL-100(Fe)). The characterization of M-MIL-100(Fe) samples was evaluated by X-ray powder diffraction (XRD), Fourier transform infrared spectra, scanning electron microscope (SEM), TGA, and N2 adsorption isotherms. The LC of M-MIL-100(Fe) and EE of ACF were determined. Nuclear magnetic resonance (NMR) and zeta-potential analyses were employed to confirm qualitatively the drug loading within M-MIL-100(Fe). Results: The ACF LC of MIL-100(Fe) was 27%, whereas the LC of M-MIL-100(Fe) was significantly increased and ranged from 37% in Ca I-MIL-100(Fe) to about 57% and 59% in Mn II-MIL-100(Fe) and Zn II-MIL-100(Fe), respectively. The ACF@M-MOFs release profiles showed slow release rates in phosphate buffer solutions at pH 6.8 and 7.4 as compared to the ACF@MIL-100(Fe). Conclusion: Therefore, M-MOFs showed a significant potential as a carrier for drug delivery systems.

dc.publisherDove Medical Press Ltd.
dc.rights.urihttps://creativecommons.org/licenses/by-nc/3.0/
dc.titleMultimetal organic frameworks as drug carriers: Aceclofenac as a drug candidate
dc.typeJournal Article
dcterms.source.volume13
dcterms.source.startPage23
dcterms.source.endPage35
dcterms.source.issn1177-8881
dcterms.source.titleDrug Design, Development and Therapy
curtin.departmentSchool of Pharmacy and Biomedical Sciences
curtin.accessStatusOpen access


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