Pericytes in Metastasis
MetadataShow full item record
Pericytes have long been known to contribute indirectly to tumour growth by regulating angiogenesis. Thus, remodelling tumour blood vessels to maintain blood supply is critical for continued tumour growth. A role for pericytes in restricting leakage of tumour cells through blood vessels has also become evident given that adequate pericyte coverage of these blood vessels is critical for maintaining vascular permeability. Interestingly, the relocation of pericytes from blood vessels to the tumour microenvironment results in the emergence of different properties in these cells that actively promote tumour growth and metastasis-functions not associated with their well-studied role in vascular stability and permeability. These form the focus of this review.
Showing items related by title, author, creator and subject.
Moorst, M.; Dass, Crispin (2011)Objectives: The high levels of morbidity and mortality associated with cancer can be attributed to two main processes; the tumour's ability to rapidly proliferate and the process of metastasis. These key processes are ...
Koina, M.; Baxter, L.; Adamson, S.; Arfuso, Frank; Hu, P.; Madigan, M.; Chan-Ling, T. (2015)Purpose. Lymphatics subserve many important functions in the human body including maintenance of fluid homeostasis, immune surveillance, and tumor metastasis. Our aim was to provide structural and phenotypic evidence of ...
Olsen, J.; Pohl, Sebastian; Deshmukh, Abhijeet; Visweswaran, Malini; Ward, Natalie; Arfuso, Frank; Agostino, Mark; Dharmarajan, Arunasalam (2017)Angiogenesis is a normal biological process wherein new blood vessels form from the growth of pre-existing blood vessels. Preventing angiogenesis in solid tumours by targeting pro-angiogenic factors including vascular ...