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    Pericytes in Metastasis

    Access Status
    Fulltext not available
    Authors
    Pieterse, Z.
    Sinha, D.
    Kaur, Pritinder
    Date
    2019
    Type
    Book Chapter
    
    Metadata
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    Citation
    Pieterse, Z. and Sinha, D. and Kaur, P. 2019. Pericytes in Metastasis. Biology of Pericytes, in Birbrair, A. (ed), Pericyte Biology in Disease. Advances in Experimental Medicine and Biology, Vol 1147, pp. 125-135. Cham: Springer.
    Source Title
    Biology of Pericytes: Development, Homeostasis & Disease
    DOI
    10.1007/978-3-030-16908-4_5
    School
    School of Pharmacy and Biomedical Sciences
    URI
    http://hdl.handle.net/20.500.11937/74819
    Collection
    • Curtin Research Publications
    Abstract

    Pericytes have long been known to contribute indirectly to tumour growth by regulating angiogenesis. Thus, remodelling tumour blood vessels to maintain blood supply is critical for continued tumour growth. A role for pericytes in restricting leakage of tumour cells through blood vessels has also become evident given that adequate pericyte coverage of these blood vessels is critical for maintaining vascular permeability. Interestingly, the relocation of pericytes from blood vessels to the tumour microenvironment results in the emergence of different properties in these cells that actively promote tumour growth and metastasis-functions not associated with their well-studied role in vascular stability and permeability. These form the focus of this review.

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