Suppression of the vestibular short-latency evoked potential by electrical stimulation of the central vestibular system
MetadataShow full item record
In an attempt to view the effects of the efferent vestibular system (EVS) on peripheral dynamic vestibular function, we have monitored the Vestibular short-latency Evoked Potential (VsEP) evoked by pulses of bone conducted vibration during electrical stimulation of the EVS neurons near the floor of the fourth ventricle in the brainstem of anesthetized guinea pigs. Given the reported effects of EVS on primary afferent activity, we hypothesized that EVS stimulation would cause a slight reduction in the VsEP amplitude. Our results show a substantial (>50%) suppression of the VsEP, occurring immediately after a single EVS current pulse. The effect could not be blocked by cholinergic drugs which have been shown to block efferent-mediated vestibular effects. Shocks produced a short-latency P1-N1 response immediately after the electrical artifact which correlated closely to the VsEP suppression. Ultimately, we have identified that this suppression results from antidromic blockade of the afferent response (the VsEP). It would appear that this effect is unavoidable for EVS stimulation, as we found no other effects.
Showing items related by title, author, creator and subject.
Dynamic response to sound and vibration of the guinea pig utricular macula, measured in vivo using Laser Doppler VibrometryPastras, C.; Curthoys, I.; Brown, Daniel (2018)With the use of a commercially available Laser Doppler Vibrometer (LDV) we have measured the velocity of the surgically exposed utricular macula in the dorsoventral plane, in anaesthetized guinea pigs, during Air Conducted ...
Hopper, Diana; Grisbrook, Tiffany; Newnham, P.; Edwards, D. (2014)This study aimed to investigate the effects of ballet-specific vestibular stimulation and fatigue on static postural control in ballet dancers and to establish whether these effects differ across varying levels of ballet ...
King, E.; Shepherd, R.; Brown, Daniel; Fallon, J. (2017)Intratympanic gentamicin therapy is widely used clinically to treat the debilitating symptoms of Ménière’s disease. Cochleotoxicity is an undesirable potential side effect of the treatment and the risk of hearing loss ...