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dc.contributor.authorKostrycki, I.
dc.contributor.authorWildner, G.
dc.contributor.authorDonato, Y.
dc.contributor.authorDos Santos, A.
dc.contributor.authorBeber, L.
dc.contributor.authorFrizzo, M.
dc.contributor.authorLudwig, M.
dc.contributor.authorKeane, Kevin
dc.contributor.authorCruzat, Vinicius
dc.contributor.authorRhoden, C.
dc.contributor.authorHeck, T.
dc.date.accessioned2019-02-19T04:18:15Z
dc.date.available2019-02-19T04:18:15Z
dc.date.created2019-02-19T03:58:11Z
dc.date.issued2019
dc.identifier.citationKostrycki, I. and Wildner, G. and Donato, Y. and Dos Santos, A. and Beber, L. and Frizzo, M. and Ludwig, M. et al. 2019. Effects of High-Fat Diet on eHSP72 and Extra-to-Intracellular HSP70 Levels in Mice Submitted to Exercise under Exposure to Fine Particulate Matter. Journal of Diabetes Research. 2019: Article ID 4858740.
dc.identifier.urihttp://hdl.handle.net/20.500.11937/74832
dc.identifier.doi10.1155/2019/4858740
dc.description.abstract

Obesity, air pollution, and exercise induce alterations in the heat shock response (HSR), in both intracellular 70?kDa heat shock proteins (iHSP70) and the plasmatic extracellular form (eHSP72). Extra-to-intracellular HSP70 ratio (H-index?=?eHSP70/iHSP70 ratio) represents a candidate biomarker of subclinical health status. This study investigated the effects of moderate- and high-intensity exercise in the HSR and oxidative stress parameters, in obese mice exposed to fine particulate matter (PM2.5). Thirty-day-old male isogenic B6129F2/J mice were maintained for 16 weeks on standard chow or high-fat diet (HFD). Then, mice were exposed to either saline or 50?µg of PM2.5 by intranasal instillation and subsequently maintained at rest or subjected to moderate- or high-intensity swimming exercise. HFD mice exhibited high adiposity and glucose intolerance at week 16th. HFD mice submitted to moderate- or high-intensity exercise were not able to complete the exercise session and showed lower levels of eHSP70 and H-index, when compared to controls. PM2.5 exposure modified the glycaemic response to exercise and modified hematological responses in HFD mice. Our study suggests that obesity is a critical health condition for exercise prescription under PM2.5 exposure.

dc.publisherHindawi Publishing Corporation
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.titleEffects of High-Fat Diet on eHSP72 and Extra-to-Intracellular HSP70 Levels in Mice Submitted to Exercise under Exposure to Fine Particulate Matter
dc.typeJournal Article
dcterms.source.volume2019
dcterms.source.issn2314-6753
dcterms.source.titleJournal of Diabetes Research
curtin.departmentSchool of Pharmacy and Biomedical Sciences
curtin.accessStatusOpen access


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