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    The role of dihydrosphingolipids in disease

    Access Status
    Fulltext not available
    Authors
    Magaye, R.
    Savira, F.
    Hua, Y.
    Kelly, D.
    Reid, Christopher
    Flynn, B.
    Liew, D.
    Wang, B.
    Date
    2018
    Type
    Journal Article
    
    Metadata
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    Citation
    Magaye, R. and Savira, F. and Hua, Y. and Kelly, D. and Reid, C. and Flynn, B. and Liew, D. et al. 2018. The role of dihydrosphingolipids in disease. Cellular and Molecular Life Sciences. 76 (6): pp. 1107–1134.
    Source Title
    Cellular and Molecular Life Sciences
    DOI
    10.1007/s00018-018-2984-8
    ISSN
    1420-682X
    School
    School of Public Health
    URI
    http://hdl.handle.net/20.500.11937/74867
    Collection
    • Curtin Research Publications
    Abstract

    Dihydrosphingolipids refer to sphingolipids early in the biosynthetic pathway that do not contain a C4-trans-double bond in the sphingoid backbone: 3-ketosphinganine (3-ketoSph), dihydrosphingosine (dhSph), dihydrosphingosine-1-phosphate (dhS1P) and dihydroceramide (dhCer). Recent advances in research related to sphingolipid biochemistry have shed light on the importance of sphingolipids in terms of cellular signalling in health and disease. However, dihydrosphingolipids have received less attention and research is lacking especially in terms of their molecular mechanisms of action. This is despite studies implicating them in the pathophysiology of disease, for example dhCer in predicting type 2 diabetes in obese individuals, dhS1P in cardiovascular diseases and dhSph in hepato-renal toxicity. This review gives a comprehensive summary of research in the last 10–15 years on the dihydrosphingolipids, 3-ketoSph, dhSph, dhS1P and dhCer, and their relevant roles in different diseases. It also highlights gaps in research that could be of future interest.

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