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    Qualitative in vivo Bioluminescence Imaging.

    Access Status
    Open access via publisher
    Authors
    Sinha, D.
    Zalitha, P.
    Kaur, Pritinder
    Date
    2018
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Sinha, D. and Zalitha, P. and Kaur, P. 2018. Qualitative in vivo Bioluminescence Imaging. Bio-protocol. 8 (18): Article ID e3020.
    Source Title
    Bio-protocol
    DOI
    10.21769/BioProtoc.3020
    Additional URLs
    https://bio-protocol.org/e3020
    School
    School of Pharmacy and Biomedical Sciences
    URI
    http://hdl.handle.net/20.500.11937/74898
    Collection
    • Curtin Research Publications
    Abstract

    Bioluminescence imaging (BLI) technology is an advanced method of carrying out molecular imaging on live laboratory animals in vivo. This powerful technique is widely-used in studying a variety of biological processes, and it has been an ideal tool in exploring tumor growth and metastatic spread in real-time. This technique ensures the optimal use of laboratory animal resources, particularly the ethical principle of reduction in animal use, given its non-invasive nature, ensuring that ongoing biological processes can be studied over time in the same animal, without the need to euthanize groups of mice at specific time points. In this protocol, the luciferase imaging technique was developed to study the effect of co-inoculating pericytes (contractile, αSMA mesenchymal stem cell-like cells, located abluminally in microvessels) on the growth and metastatic spread of ovarian cancers using an aggressive ovarian cancer cell line–OVCAR-5–as an example.

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