Antiprotozoals based on the inhibition of N-Myristoyltransferase
MetadataShow full item record
The research performed a protozoal structure activity investigation based on the transition state of N-Myristoyltransferase. This initial investigation synthesised a simplified transition state mimetic based from myristic acid and included alkene and phenoxy variation of the myristoyl chain. A series of Inhibitors were developed using a coenzyme-A fragment. Structures were targeted that were based on the statins (HMG-CoA inhibitors). Some of the compounds developed showed micro molar activities towards T. brucei and P. falciparum.
Showing items related by title, author, creator and subject.
Nusit, K.; Jitsangiam, Peerapong; Nikraz, Hamid; Hewa Thalagahage, R. (2014)Cement-treated base is a conveniently and effectively stabilised pavement material consisting of a mixture of standard base course materials blended with a prescribed amount of Portland cement and water. The cement-treated ...
Siripun, Komsun (2010)Western Australia (WA) has a road network of approximately 177,700 km, including a 17,800 km stage highway system (Main Roads Western Australia 2009). This infrastructure supports a population of only about two million, ...
Nematollahi, B.; Sanjayan, J.; Shaikh, Faiz (2014)This paper presents the effects of four different activator combinations including twosodium-based (Na-based) and one potassium-based (K-based) activator combinationsin the form of solution and one calcium-based (Ca-based) ...