Antiprotozoals based on the inhibition of N-Myristoyltransferase
Access Status
Open access
Authors
Clegg, Robert Alexander Norman
Date
2018Supervisor
Alan Payne
Type
Thesis
Award
PhD
Metadata
Show full item recordFaculty
Science and Engineering
School
School of Molecular and Life Sciences
Collection
Abstract
The research performed a protozoal structure activity investigation based on the transition state of N-Myristoyltransferase. This initial investigation synthesised a simplified transition state mimetic based from myristic acid and included alkene and phenoxy variation of the myristoyl chain. A series of Inhibitors were developed using a coenzyme-A fragment. Structures were targeted that were based on the statins (HMG-CoA inhibitors). Some of the compounds developed showed micro molar activities towards T. brucei and P. falciparum.
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