Antiprotozoals based on the inhibition of N-Myristoyltransferase
dc.contributor.author | Clegg, Robert Alexander Norman | |
dc.contributor.supervisor | Alan Payne | en_US |
dc.date.accessioned | 2019-02-25T05:46:37Z | |
dc.date.available | 2019-02-25T05:46:37Z | |
dc.date.issued | 2018 | en_US |
dc.identifier.uri | http://hdl.handle.net/20.500.11937/74927 | |
dc.description.abstract |
The research performed a protozoal structure activity investigation based on the transition state of N-Myristoyltransferase. This initial investigation synthesised a simplified transition state mimetic based from myristic acid and included alkene and phenoxy variation of the myristoyl chain. A series of Inhibitors were developed using a coenzyme-A fragment. Structures were targeted that were based on the statins (HMG-CoA inhibitors). Some of the compounds developed showed micro molar activities towards T. brucei and P. falciparum. | en_US |
dc.publisher | Curtin University | en_US |
dc.title | Antiprotozoals based on the inhibition of N-Myristoyltransferase | en_US |
dc.type | Thesis | en_US |
dcterms.educationLevel | PhD | en_US |
curtin.department | School of Molecular and Life Sciences | en_US |
curtin.accessStatus | Open access | en_US |
curtin.faculty | Science and Engineering | en_US |