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dc.contributor.authorClegg, Robert Alexander Norman
dc.contributor.supervisorAlan Payneen_US

The research performed a protozoal structure activity investigation based on the transition state of N-Myristoyltransferase. This initial investigation synthesised a simplified transition state mimetic based from myristic acid and included alkene and phenoxy variation of the myristoyl chain. A series of Inhibitors were developed using a coenzyme-A fragment. Structures were targeted that were based on the statins (HMG-CoA inhibitors). Some of the compounds developed showed micro molar activities towards T. brucei and P. falciparum.

dc.publisherCurtin Universityen_US
dc.titleAntiprotozoals based on the inhibition of N-Myristoyltransferaseen_US
curtin.departmentSchool of Molecular and Life Sciencesen_US
curtin.accessStatusOpen accessen_US
curtin.facultyScience and Engineeringen_US

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