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dc.contributor.authorSindi, Rooa
dc.contributor.authorSa dos Reis, Claudia
dc.contributor.authorBennett, Colleen
dc.contributor.authorStevenson, G.
dc.contributor.authorSun, Zhonghua
dc.date.accessioned2019-05-27T01:50:51Z
dc.date.available2019-05-27T01:50:51Z
dc.date.issued2019
dc.identifier.citationSindi, R. and Sa dos Reis, C. and Bennett, C. and Stevenson, G. and Sun, Z. 2019. Quantitative Measurements of Breast Density Using Magnetic Resonance Imaging: A Systematic Review and Meta-Analysis. Journal of Clinical Medicine. 8 (5): 745.
dc.identifier.urihttp://hdl.handle.net/20.500.11937/75547
dc.identifier.doi10.3390/jcm8050745
dc.description.abstract

Breast density, a measure of dense fibroglandular tissue relative to non-dense fatty tissue, is confirmed as an independent risk factor of breast cancer. Although there has been an increasing interest in the quantitative assessment of breast density, no research has investigated the optimal technical approach of breast MRI in this aspect. Therefore, we performed a systematic review and meta-analysis to analyze the current studies on quantitative assessment of breast density using MRI and to determine the most appropriate technical/operational protocol. Databases (PubMed, EMBASE, ScienceDirect, and Web of Science) were searched systematically for eligible studies. Single arm meta-analysis was conducted to determine quantitative values of MRI in breast density assessments. Combined means with their 95% confidence interval (CI) were calculated using a fixedeffect model. In addition, subgroup meta-analyses were performed with stratification by breast density segmentation/measurement method. Furthermore, alternative groupings based on statistical similarities were identified via a cluster analysis employing study means and standard deviations in a Nearest Neighbor/Single Linkage. A total of 38 studies matched the inclusion criteria for this systematic review. Twenty-one of these studies were judged to be eligible for meta-analysis. The results indicated, generally, high levels of heterogeneity between study means within groups and high levels of heterogeneity between study variances within groups. The studies in two main clusters identified by the cluster analysis were also subjected to meta-analyses. The review confirmed high levels of heterogeneity within the breast density studies, considered to be due mainly to the applications of MR breast-imaging protocols and the use of breast density segmentation/measurement methods. Further research should be performed to determine the most appropriate protocol and method for quantifying breast density using MRI.

dc.publisherMDPI AG
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectMagnetic resonance imaging; breast density; fibroglandular-tissue; systematic review
dc.titleQuantitative Measurements of Breast Density Using Magnetic Resonance Imaging: A Systematic Review and Meta-Analysis
dc.typeJournal Article
dcterms.source.volume8
dcterms.source.number745
dcterms.source.startPage1
dcterms.source.endPage23
dcterms.source.issn2077-0383
dcterms.source.titleJournal of Clinical Medicine
dc.date.updated2019-05-27T01:50:51Z
curtin.departmentSchool of Molecular and Life Sciences (MLS)
curtin.accessStatusOpen access
curtin.facultyFaculty of Science and Engineering
curtin.contributor.orcidSun, Zhonghua [0000-0002-7538-4761]
curtin.contributor.researcheridSun, Zhonghua [B-3125-2010]
curtin.contributor.scopusauthoridSun, Zhonghua [12544503300]


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