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    The Link Between Diabetes, Glucose Control, and Alzheimer's Disease and Neurodegenerative Diseases

    Access Status
    Fulltext not available
    Authors
    Verdile, Giuseppe
    Fraser, P.
    Martins, R.
    Date
    2019
    Type
    Book Chapter
    
    Metadata
    Show full item record
    Source Title
    Neurodegeneration and Alzheimer's Disease: The Role of Diabetes, Genetics, Hormones, and Lifestyle
    DOI
    10.1002/9781119356752.ch4
    ISBN
    9781119356752
    Faculty
    Faculty of Health Sciences
    School
    School of Pharmacy and Biomedical Sciences
    URI
    http://hdl.handle.net/20.500.11937/75631
    Collection
    • Curtin Research Publications
    Abstract

    Largely as a result of increases in life expectancy in most countries, as well as changes in lifestyle over the last few decades, chronic diseases such as Type 2 diabetes (T2D) and dementia are increasing in prevalence. A wealth of evidence indicates a strong link between T2D and the development of neurodegenerative diseases such as Alzheimer's disease (AD). Although the precise mechanisms remain unclear, there is now strong evidence T2D and AD have many aspects in common, and that T2D can exacerbate neurodegenerative processes. Brain atrophy, reduced cerebral glucose metabolism, and central nervous system (CNS) insulin resistance are features of both AD and T2D. The T2D phenotype (glucose dyshomeostasis, insulin resistance, impaired insulin signalling) also promotes AD pathology, namely the accumulation of Aβ and hyperphosphorylated tau, and can induce other aspects of neuronal degeneration including inflammatory and oxidative processes. This chapter discusses the evidence and potential underlying mechanisms that link these two chronic diseases of ageing. The potential of common treatments for the management of diabetes as therapies for AD are also discussed.

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