The Influence of Cholesterol on β-cell Function
dc.contributor.author | Ellison, Gaewyn Colleen | |
dc.contributor.supervisor | Cyril Mamotte | en_US |
dc.date.accessioned | 2019-07-29T03:42:50Z | |
dc.date.available | 2019-07-29T03:42:50Z | |
dc.date.issued | 2019 | en_US |
dc.identifier.uri | http://hdl.handle.net/20.500.11937/76106 | |
dc.description.abstract |
Strong evidence that statin medication is linked to type II diabetes raises questions about the role of cholesterol in insulin secretion and pancreatic β-cell function. Experimentally induced changes in cellular cholesterol content attenuated insulin secretion robustly stimulated by both nutrient and therapeutic secretagogues in β-cell models. The mechanisms of these adverse effects were investigated, including aspects of cellular metabolism, mitochondrial dysfunction, and effects on strategic proteins involved in glucose sensing, exocytosis and cholesterol transport. | en_US |
dc.publisher | Curtin University | en_US |
dc.title | The Influence of Cholesterol on β-cell Function | en_US |
dc.type | Thesis | en_US |
dcterms.educationLevel | PhD | en_US |
curtin.department | School of Pharmacy and Biomedical Science | en_US |
curtin.department | Curtin Health Innovation Research Institute | en_US |
curtin.accessStatus | Open access | en_US |
curtin.faculty | Health Sciences | en_US |