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    Effects of a high-fat, high-cholesterol diet on brain lipid profiles in apolipoprotein E ε3 and ε4 knock-in mice

    Access Status
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    Authors
    Lim, Wei Ling
    Lam, Sin Man
    Shui, Guanghou
    Mondal, Alinda
    Ong, Daniel
    Duan, Xinrui
    Creegan, Rhona
    martins, Ian
    Sharman, Matthew
    Taddei, Kevin
    Verdile, Giuseppe
    Wenk, Markus
    Martins, Ralph
    Date
    2013
    Type
    Journal Article
    
    Metadata
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    Citation
    Lim, Wei Ling Florence and Lam, Sin Man and Shui, Guanghou and Mondal, Alinda and Ong, Daniel and Duan, Xinrui and Creegan, Rhona et al. 2013. Effects of a high-fat, high-cholesterol diet on brain lipid profiles in apolipoprotein E ε3 and ε4 knock-in mice. Neurobiology of Aging. 34: pp. 2217-2224.
    Source Title
    Neurobiology of Aging
    DOI
    10.1016/j.neurobiolaging.2013.03.012
    ISSN
    0197-4580
    URI
    http://hdl.handle.net/20.500.11937/44156
    Collection
    • Curtin Research Publications
    Abstract

    Apolipoprotein E (ApoE) is important in facilitating the transport of lipids (cholesterol, phospholipids, and sulfatides) and plays a fundamental role in normal lipid metabolism. High cholesterol levels increases the risk of developing Alzheimer’s disease. In this study, we investigated the effects of a high-fat high cholesterol (HFHC) diet on brain lipid profiles in 95 young and aged APOE ε3 and ε4 knock-in mice to determine whether diet leads to altered brain levels of a number of glycerophospholipids, sphingolipids, cholesterol precursors, cholesterol, cholesterol oxidation products, and cholesterol esters. The results in this study revealed significant changes in lipid levels. The HFHC-enriched diet influenced the levels of cholesterol esters. A sharp increase in cholesterol ester levels, particularly in the aged APOE ε4 diet-enriched group, might be suggestive of abnormal acyl-coenzyme A:cholesterol acyltransferase 1 (ACAT) activity and/or levels. Age exerts appreciable effects on the brain lipidome, especially with regard to polar lipid species.

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