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dc.contributor.authorDorakumbura, Buddhika
dc.contributor.authorBusetti, F.
dc.contributor.authorLewis, Simon
dc.date.accessioned2019-11-07T00:25:46Z
dc.date.available2019-11-07T00:25:46Z
dc.date.issued2019
dc.identifier.citationDorakumbura, B.N. and Busetti, F. and Lewis, S.W. 2019. Analysis of squalene and its transformation by-products in latent fingermarks by ultrahigh-performance liquid chromatography-high resolution accurate mass Orbitrap™ mass spectrometry. Forensic Chemistry. 14: Article No. 100193.
dc.identifier.urihttp://hdl.handle.net/20.500.11937/76758
dc.identifier.doi10.1016/j.forc.2019.100193
dc.description.abstract

Transformation of squalene and its by-products in latent fingermarks over time under different storage conditions (light, dark, and underwater) was examined through ultrahigh-performance liquid chromatography-high resolution accurate mass Orbitrap™ mass spectrometry. Complications of assessing fingermark compositional variation over time using multiple samples with varying initial compositions were elucidated and a more rational approach was successfully demonstrated. Squalene was detected in all fresh natural fingermarks deposited on non-porous surfaces and the amount ranged between 0.20 to 11.32 μg/5 fingertips. A notable difference in the transformation of squalene was observed with different storage conditions, where a dark aquatic environment accelerated degradation of squalene compared to dark but dry conditions. Squalene monohydroperoxide was extremely short-lived in natural deposits while the amount of squalene epoxide was still increasing relative to the initial amount, after ageing under dark and aquatic conditions for up to 7 days. Some oxidation by-products of cholesterol were also tentatively identified, which exhibited a growth over time against their initial concentration under any of the storage condition tested. These by-products, therefore, show potential as biomarkers for targeted visualisation of aged deposits.

dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectFingermark composition
dc.subjectDegradation
dc.subjectSqualene
dc.subjectBy-products
dc.subjectHigh resolution accurate mass Orbitrap™ mass spectrometry
dc.titleAnalysis of squalene and its transformation by-products in latent fingermarks by ultrahigh-performance liquid chromatography-high resolution accurate mass Orbitrap™ mass spectrometry
dc.typeJournal Article
dcterms.source.startPage100193
dcterms.source.issn2468-1709
dcterms.source.titleForensic Chemistry
dc.date.updated2019-11-07T00:25:46Z
curtin.departmentSchool of Molecular and Life Sciences (MLS)
curtin.accessStatusOpen access
curtin.facultyFaculty of Science and Engineering
curtin.contributor.orcidLewis, Simon [0000-0002-2049-1586]
curtin.contributor.scopusauthoridLewis, Simon [7404038754]


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