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dc.contributor.authorShepherd, C.C.J.
dc.contributor.authorClifford, H.D.
dc.contributor.authorMitrou, F.
dc.contributor.authorMelody, S.M.
dc.contributor.authorBennett, E.J.
dc.contributor.authorJohnston, F.H.
dc.contributor.authorKnibbs, L.D.
dc.contributor.authorPereira, Gavin
dc.contributor.authorPickering, J.L.
dc.contributor.authorTeo, T.H.
dc.contributor.authorKirkham, L.A.S.
dc.contributor.authorThornton, R.B.
dc.contributor.authorKicic, Anthony
dc.contributor.authorLing, K.M.
dc.contributor.authorAlach, Z.
dc.contributor.authorLester, M.
dc.contributor.authorFranklin, P.
dc.contributor.authorReid, D.
dc.contributor.authorZosky, G.R.
dc.identifier.citationShepherd, C.C.J. and Clifford, H.D. and Mitrou, F. and Melody, S.M. and Bennett, E.J. and Johnston, F.H. and Knibbs, L.D. et al. 2019. The contribution of geogenic particulate matter to lung disease in indigenous children. International Journal of Environmental Research and Public Health. 16 (15): ARTN 2636.

© 2019 by the authors. Licensee MDPI, Basel, Switzerland. Indigenous children have much higher rates of ear and lung disease than non-Indigenous children, which may be related to exposure to high levels of geogenic (earth-derived) particulate matter (PM). The aim of this study was to assess the relationship between dust levels and health in Indigenous children in Western Australia (W.A.). Data were from a population-based sample of 1077 Indigenous children living in 66 remote communities of W.A. (>2,000,000 km2), with information on health outcomes derived from carer reports and hospitalisation records. Associations between dust levels and health outcomes were assessed by multivariate logistic regression in a multi-level framework. We assessed the effect of exposure to community sampled PM on epithelial cell (NuLi-1) responses to non-typeable Haemophilus influenzae (NTHi) in vitro. High dust levels were associated with increased odds of hospitalisation for upper (OR 1.77 95% CI [1.02–3.06]) and lower (OR 1.99 95% CI [1.08–3.68]) respiratory tract infections and ear disease (OR 3.06 95% CI [1.20–7.80]). Exposure to PM enhanced NTHi adhesion and invasion of epithelial cells and impaired IL-8 production. Exposure to geogenic PM may be contributing to the poor respiratory health of disadvantaged communities in arid environments where geogenic PM levels are high.

dc.subjectScience & Technology
dc.subjectLife Sciences & Biomedicine
dc.subjectEnvironmental Sciences
dc.subjectPublic, Environmental & Occupational Health
dc.subjectEnvironmental Sciences & Ecology
dc.subjectchild health
dc.subjectparticulate matter
dc.subjectbacterial infection
dc.titleThe contribution of geogenic particulate matter to lung disease in indigenous children
dc.typeJournal Article
dcterms.source.titleInternational Journal of Environmental Research and Public Health
curtin.departmentSchool of Public Health
curtin.accessStatusOpen access
curtin.facultyFaculty of Health Sciences
curtin.contributor.orcidPereira, Gavin [0000-0003-3740-8117]
curtin.contributor.orcidKicic, Anthony [0000-0002-0008-9733]
curtin.contributor.researcheridPereira, Gavin [D-7136-2014]
curtin.identifier.article-numberARTN 2636
curtin.contributor.scopusauthoridPereira, Gavin [35091486200]
curtin.contributor.scopusauthoridKicic, Anthony [6507472922]

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