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    Interleukin-1 is associated with inflammation and structural lung disease in young children with cystic fibrosis

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    Authors
    Montgomery, S.T.
    Dittrich, A.S.
    Garratt, L.W.
    Turkovic, L.
    Frey, D.L.
    Stick, S.M.
    Mall, M.A.
    Kicic, Anthony
    Date
    2018
    Type
    Journal Article
    
    Metadata
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    Citation
    Montgomery, S.T. and Dittrich, A.S. and Garratt, L.W. and Turkovic, L. and Frey, D.L. and Stick, S.M. and Mall, M.A. et al. 2018. Interleukin-1 is associated with inflammation and structural lung disease in young children with cystic fibrosis. Journal of Cystic Fibrosis. 17 (6): pp. 715-722.
    Source Title
    Journal of Cystic Fibrosis
    DOI
    10.1016/j.jcf.2018.05.006
    ISSN
    1569-1993
    Faculty
    Faculty of Health Sciences
    School
    School of Public Health
    URI
    http://hdl.handle.net/20.500.11937/76797
    Collection
    • Curtin Research Publications
    Abstract

    © 2018 European Cystic Fibrosis Society Background: Little is known about the role of interleukin (IL)-1 in the pathogenesis of cystic fibrosis (CF) lung disease. This study investigated the relationship between IL-1 signalling, neutrophilic inflammation and structural lung changes in children with CF. Methods: Bronchoalveolar lavage fluid (BALf) from 102 children with CF were used to determine IL-1α, IL-1β, IL-8 levels and neutrophil elastase (NE) activity, which were then correlated to structural lung changes observed on chest computed tomography (CT) scans. Results: IL-1α and IL-1β were detectable in BAL in absence of infection, increased in the presence of bacterial infection and correlated with IL-8 (p < 0.0001), neutrophils (p < 0.0001) and NE activity (p < 0.01 and p < 0.001). IL-1α had the strongest association with structural lung disease (p < 0.01) in the absence of infection (uninfected: p < 0.01 vs. infected: p = 0.122). Conclusion: Our data associates IL-1α with early structural lung damage in CF and suggests this pathway as a novel anti-inflammatory target.

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