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    Anti-diabetic action of Lupinus angustifolius seed proteins and peptides

    Tapadia M 2019.pdf (4.496Mb)
    Access Status
    Open access
    Authors
    Tapadia, Mrunmai
    Date
    2019
    Supervisor
    Ranjeet Utikar
    Type
    Thesis
    Award
    PhD
    
    Metadata
    Show full item record
    Faculty
    Science and Engineering
    School
    WASM: Minerals, Energy and Chemical Engineering
    URI
    http://hdl.handle.net/20.500.11937/77246
    Collection
    • Curtin Theses
    Abstract

    Lupin seed proteins have been reported to exhibit hypoglycaemic action in animals and humans. This research focuses on exploring in-vitro anti-diabetic action of proteins extracted from Lupinus angustifolius seed. A novel insulin secretory mechanism of extract hydrolysate mediating through Gaq protein signalling pathway in pancreatic ß-cells was established. γ-conglutin protein, a glucose modulating agent, was separated from the extract. Purified γ-conglutin was characterised and hydrolysed to evaluate its anti-diabetic properties in pancreatic ß-cells and myotubes.

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