The role of genetic diversity in the replication, pathogenicity and virulence of Murray Valley encephalitis virus
Assoc. Prof. Cheryl Johansen
Dr Beng Hooi Chua
Dr Paul Costantino
Dr David Thomas Williams
Prof. Ricardo Mancera
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School of Biomedical Sciences
Genetic and phenotypic variation of genotype 1 (G1) and genotype 2 (G2) Murray valley encephalitis virus (MVEV) were characterised. G2 viruses were a minority, had lower levels of genetic diversity and an attenuated phenotype in the mouse model of MVE. G1 isolates were abundant with higher levels of genetic diversity and a virulent phenotype. The restricted evolution of MVEV was due to multiplication in mosquito cells. An RT-qPCR assay detecting all MVEV genotypes was developed.
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