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dc.contributor.authorNiazi, Aziz-ur-Rahman
dc.contributor.supervisorAssoc. Prof. Cheryl Johansen
dc.contributor.supervisorDr Beng Hooi Chua
dc.contributor.supervisorDr Paul Costantino
dc.contributor.supervisorDr David Thomas Williams
dc.contributor.supervisorProf. Ricardo Mancera

Genetic and phenotypic variation of genotype 1 (G1) and genotype 2 (G2) Murray valley encephalitis virus (MVEV) were characterised. G2 viruses were a minority, had lower levels of genetic diversity and an attenuated phenotype in the mouse model of MVE. G1 isolates were abundant with higher levels of genetic diversity and a virulent phenotype. The restricted evolution of MVEV was due to multiplication in mosquito cells. An RT-qPCR assay detecting all MVEV genotypes was developed.

dc.publisherCurtin University
dc.titleThe role of genetic diversity in the replication, pathogenicity and virulence of Murray Valley encephalitis virus
curtin.departmentSchool of Biomedical Sciences
curtin.accessStatusOpen access

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