The role of genetic diversity in the replication, pathogenicity and virulence of Murray Valley encephalitis virus
| dc.contributor.author | Niazi, Aziz-ur-Rahman | |
| dc.contributor.supervisor | Assoc. Prof. Cheryl Johansen | |
| dc.contributor.supervisor | Dr Beng Hooi Chua | |
| dc.contributor.supervisor | Dr Paul Costantino | |
| dc.contributor.supervisor | Dr David Thomas Williams | |
| dc.contributor.supervisor | Prof. Ricardo Mancera | |
| dc.date.accessioned | 2017-01-30T09:53:31Z | |
| dc.date.available | 2017-01-30T09:53:31Z | |
| dc.date.created | 2015-05-08T00:09:44Z | |
| dc.date.issued | 2013 | |
| dc.identifier.uri | http://hdl.handle.net/20.500.11937/774 | |
| dc.description.abstract |
Genetic and phenotypic variation of genotype 1 (G1) and genotype 2 (G2) Murray valley encephalitis virus (MVEV) were characterised. G2 viruses were a minority, had lower levels of genetic diversity and an attenuated phenotype in the mouse model of MVE. G1 isolates were abundant with higher levels of genetic diversity and a virulent phenotype. The restricted evolution of MVEV was due to multiplication in mosquito cells. An RT-qPCR assay detecting all MVEV genotypes was developed. | |
| dc.language | en | |
| dc.publisher | Curtin University | |
| dc.title | The role of genetic diversity in the replication, pathogenicity and virulence of Murray Valley encephalitis virus | |
| dc.type | Thesis | |
| dcterms.educationLevel | PhD | |
| curtin.department | School of Biomedical Sciences | |
| curtin.accessStatus | Open access |