Investigation of Novel Biomarkers for Pancreatic Cancer

Emmanouilidi, Aikaterini

Emmanouilidi A 2019.pdf (24.37Mb)

Access Status

Open access

Authors

Emmanouilidi, Aikaterini

Date

2019

Supervisor

Marco Falasca

Pat Metharom

Type

Thesis

Award

PhD

Metadata

Show full item record

Faculty

Health Sciences

School

School of Pharmacy and Biomedical Sciences

URI

http://hdl.handle.net/20.500.11937/78328

Collection

Curtin Theses

Abstract

Pancreatic ductal adenocarcinoma (PDAC) is a disease with dismal prognosis and an 8% chance of survival 5 years post-diagnosis, and is very challenging diagnostically and therapeutically. Exosomes are nanometre-sized vesicles known to mediate cancer spread and chemotherapy resistance. In this study, a comprehensive proteomic and lipidomic analysis of PDAC-derived exosomes has been performed. A specific enrichment of key signalling proteins and lipids with a potential role in PDAC progression has been identified.