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dc.contributor.authorNewton, R.U.
dc.contributor.authorChristophersen, Claus
dc.contributor.authorFairman, C.M.
dc.contributor.authorHart, N.H.
dc.contributor.authorTaaffe, D.R.
dc.contributor.authorBroadhurst, D.
dc.contributor.authorDevine, A.
dc.contributor.authorChee, R.
dc.contributor.authorTang, C.I.
dc.contributor.authorSpry, N.
dc.contributor.authorGalvão, D.A.
dc.date.accessioned2020-05-14T04:17:47Z
dc.date.available2020-05-14T04:17:47Z
dc.date.issued2019
dc.identifier.citationNewton, R.U. and Christophersen, C.T. and Fairman, C.M. and Hart, N.H. and Taaffe, D.R. and Broadhurst, D. and Devine, A. et al. 2019. Does exercise impact gut microbiota composition in men receiving androgen deprivation therapy for prostate cancer? A single-blinded, two-armed, randomised controlled trial. BMJ Open. 9 (4): Article No. e024872.
dc.identifier.urihttp://hdl.handle.net/20.500.11937/79125
dc.identifier.doi10.1136/bmjopen-2018-024872
dc.description.abstract

Introduction: A potential link exists between prostate cancer (PCa) disease and treatment and increased inflammatory levels from gut dysbiosis. This study aims to examine if exercise favourably alters gut microbiota in men receiving androgen deprivation therapy (ADT) for PCa. Specifically, this study will explore whether: (1) exercise improves the composition of gut microbiota and increases the abundance of bacteria associated with health promotion and (2) whether gut health correlates with favourable inflammatory status, bowel function, continence and nausea among patients participating in the exercise intervention. Methods and analysis: A single-blinded, two-armed, randomised controlled trial will explore the influence of a 3-month exercise programme (3 days/week) for men with high-risk localised PCa receiving ADT. Sixty patients will be randomly assigned to either exercise intervention or usual care. The primary endpoint (gut health and function assessed via feacal samples) and secondary endpoints (self-reported quality of life via standardised questionnaires, blood biomarkers, body composition and physical fitness) will be measured at baseline and following the intervention. A variety of statistical methods will be used to understand the covariance between microbial diversity and metabolomics profile across time and intervention. An intention-to-treat approach will be utilised for the analyses with multiple imputations followed by a secondary sensitivity analysis to ensure data robustness using a complete cases approach. Ethics and dissemination: Ethics approval was obtained from the Human Research Ethics Committee of Edith Cowan University (ID: 19827 NEWTON). Findings will be reported in peer-reviewed publications and scientific conferences in addition to working with national support groups to translate findings for the broader community. If exercise is shown to result in favourable changes in gut microbial diversity, composition and metabolic profile, and reduce gastrointestinal complications in PCa patients receiving ADT, this study will form the basis of a future phase III trial. Trial registration number ANZCTR12618000280202.

dc.languageEnglish
dc.publisherBMJ PUBLISHING GROUP
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/
dc.subjectScience & Technology
dc.subjectLife Sciences & Biomedicine
dc.subjectMedicine, General & Internal
dc.subjectGeneral & Internal Medicine
dc.subjectQUALITY-OF-LIFE
dc.subjectFECAL MICROBIOTA
dc.subjectSEX-DIFFERENCES
dc.subjectHEALTH
dc.subjectQUESTIONNAIRE
dc.subjectDIET
dc.subjectOUTCOMES
dc.subjectDISEASE
dc.subjectOBESITY
dc.subjectFAT
dc.titleDoes exercise impact gut microbiota composition in men receiving androgen deprivation therapy for prostate cancer? A single-blinded, two-armed, randomised controlled trial
dc.typeJournal Article
dcterms.source.volume9
dcterms.source.number4
dcterms.source.issn2044-6055
dcterms.source.titleBMJ Open
dc.date.updated2020-05-14T04:17:47Z
curtin.note

© Authors. This article was published in BMJ Open following peer review and can also be viewed on the journal’s website at http://dx.doi.org/10.1136/bmjopen-2018-024872.

curtin.departmentSchool of Molecular and Life Sciences (MLS)
curtin.accessStatusOpen access
curtin.facultyFaculty of Science and Engineering
curtin.contributor.orcidChristophersen, Claus [0000-0003-1591-5871]
curtin.identifier.article-numberARTN e024872
dcterms.source.eissn2044-6055
curtin.contributor.scopusauthoridChristophersen, Claus [7006206487]


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