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dc.contributor.authorDeering, K.E.
dc.contributor.authorDevine, A.
dc.contributor.authorO’sullivan, T.A.
dc.contributor.authorLo, J.
dc.contributor.authorBoyce, M.C.
dc.contributor.authorChristophersen, Claus
dc.date.accessioned2020-05-14T04:22:34Z
dc.date.available2020-05-14T04:22:34Z
dc.date.issued2020
dc.identifier.citationDeering, K.E. and Devine, A. and O’sullivan, T.A. and Lo, J. and Boyce, M.C. and Christophersen, C.T. 2020. Characterizing the composition of the pediatric gut microbiome: A systematic review. Nutrients. 12 (1): Article No. 16.
dc.identifier.urihttp://hdl.handle.net/20.500.11937/79129
dc.identifier.doi10.3390/nu12010016
dc.description.abstract

The consortium of trillions of microorganisms that live inside the human gut are integral to health. Little has been done to collate and characterize the microbiome of children. A systematic review was undertaken to address this gap (PROSPERO ID: CRD42018109599). MEDLINE and EMBASE were searched using the keywords: “healthy preadolescent children” and “gut microbiome” to 31 August 2018. Of the 815 journal articles, 42 met the inclusion criteria. The primary outcome was the relative abundance of bacteria at the phylum, family, and genus taxonomic ranks. α-diversity, short chain fatty acid concentrations, diet, 16S rRNA sequencing region, and geographical location were documented. The preadolescent gut microbiome is dominated at the phylum level by Firmicutes (weighted overall average relative abundance = 51.1%) and Bacteroidetes (36.0%); genus level by Bacteroides (16.0%), Prevotella (8.69%), Faecalibacterium (7.51%), and Bifidobacterium (5.47%). Geographic location and 16S rRNA sequencing region were independently associated with microbial proportions. There was limited consensus between studies that reported α-diversity and short chain fatty acids. Broadly speaking, participants from nonWestern locations, who were less likely to follow a Westernized dietary pattern, had higher αdiversity and SCFA concentrations. Confirmatory studies will increase the understanding of the composition and functional capacity of the preadolescent gut microbiome.

dc.languageEnglish
dc.publisherMDPI
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectScience & Technology
dc.subjectLife Sciences & Biomedicine
dc.subjectNutrition & Dietetics
dc.subjectgut microbiome
dc.subjectgut microbiota
dc.subjectgut health
dc.subjectpediatrics
dc.subjectchildren
dc.subjectdiet
dc.subjectshort chain fatty acid
dc.subjectSCFA
dc.subjectreview
dc.subjectCHAIN FATTY-ACIDS
dc.subjectFECAL MICROBIOTA
dc.subjectBIFIDOBACTERIUM-LACTIS
dc.subjectPRESCHOOL-CHILDREN
dc.subjectDIETARY PATTERNS
dc.subjectCONTROLLED-TRIAL
dc.subjectCOMB. NOV.
dc.subjectEARLY-LIFE
dc.subjectOBESITY
dc.subjectASSOCIATION
dc.titleCharacterizing the composition of the pediatric gut microbiome: A systematic review
dc.typeJournal Article
dcterms.source.volume12
dcterms.source.number1
dcterms.source.issn2072-6643
dcterms.source.titleNutrients
dc.date.updated2020-05-14T04:22:33Z
curtin.note

© Authors. Published by MDPI Publishing.

curtin.departmentSchool of Molecular and Life Sciences (MLS)
curtin.accessStatusOpen access
curtin.facultyFaculty of Science and Engineering
curtin.contributor.orcidChristophersen, Claus [0000-0003-1591-5871]
curtin.identifier.article-numberARTN 16
dcterms.source.eissn2072-6643
curtin.contributor.scopusauthoridChristophersen, Claus [7006206487]


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