Show simple item record

dc.contributor.authorWest, N.P.
dc.contributor.authorPyne, D.B.
dc.contributor.authorCripps, A.W.
dc.contributor.authorHopkins, W.G.
dc.contributor.authorEskesen, D.C.
dc.contributor.authorJairath, A.
dc.contributor.authorChristophersen, Claus
dc.contributor.authorConlon, M.A.
dc.contributor.authorFricker, P.A.
dc.identifier.citationWest, N.P. and Pyne, D.B. and Cripps, A.W. and Hopkins, W.G. and Eskesen, D.C. and Jairath, A. and Christophersen, C.T. et al. 2011. Lactobacillus fermentum (PCC) supplementation and gastrointestinal and respiratory-tract illness symptoms: A randomised control trial in athletes. Nutrition Journal. 10 (1): ARTN 30.

Background: Probiotics purportedly reduce symptoms of gastrointestinal and upper respiratory-tract illness by modulating commensal microflora. Preventing and reducing symptoms of respiratory and gastrointestinal illness are the primary reason that dietary supplementation with probiotics are becoming increasingly popular with healthy active individuals. There is a paucity of data regarding the effectiveness of probiotics in this cohort. The aim of this study was to evaluate the effectiveness of a probiotic on faecal microbiology, self-reported illness symptoms and immunity in healthy well trained individuals. Methods. Competitive cyclists (64 males and 35 females; age 35 9 and 36 9 y, VO2max 56 6 and 52 6, mean SD) were randomised to either probiotic (minimum 1 × 109 Lactobacillus fermentum (PCC) per day) or placebo treatment for 11 weeks in a double-blind, randomised, controlled trial. The outcome measures were faecal L. fermentum counts, self-reported symptoms of illness and serum cytokines. Results: Lactobacillus numbers increased 7.7-fold (90% confidence limits 2.1- to 28-fold) more in males on the probiotic, while there was an unclear 2.2-fold (0.2- to 18-fold) increase in females taking the probiotic. The number and duration of mild gastrointestinal symptoms were ∼2-fold greater in the probiotic group. However, there was a substantial 0.7 (0.2 to 1.2) of a scale step reduction in the severity of gastrointestinal illness at the mean training load in males, which became more pronounced as training load increased. The load (duration×severity) of lower respiratory illness symptoms was less by a factor of 0.31 (99%CI; 0.07 to 0.96) in males taking the probiotic compared with placebo but increased by a factor of 2.2 (0.41 to 27) in females. Differences in use of cold and flu medication mirrored these symptoms. The observed effects on URTI had too much uncertainty for a decisive outcome. There were clear reductions in the magnitude of acute exercise-induced changes in some cytokines. Conclusion: L. fermentum may be a useful nutritional adjunct for healthy exercising males. However, uncertainty in the effects of supplementation on URTI and on symptoms in females needs to be resolved. © 2011 West et al; licensee BioMed Central Ltd.

dc.subjectScience & Technology
dc.subjectLife Sciences & Biomedicine
dc.subjectNutrition & Dietetics
dc.subjectREAL-TIME PCR
dc.subjectCOMMON COLD
dc.subjectHUMAN FECES
dc.titleLactobacillus fermentum (PCC) supplementation and gastrointestinal and respiratory-tract illness symptoms: A randomised control trial in athletes
dc.typeJournal Article
dcterms.source.titleNutrition Journal
curtin.departmentSchool of Molecular and Life Sciences (MLS)
curtin.accessStatusOpen access
curtin.facultyFaculty of Science and Engineering
curtin.contributor.orcidChristophersen, Claus [0000-0003-1591-5871]
curtin.identifier.article-numberARTN 30
curtin.contributor.scopusauthoridChristophersen, Claus [7006206487]

Files in this item


This item appears in the following Collection(s)

Show simple item record
Except where otherwise noted, this item's license is described as