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    Immunogenicity of the inactivated influenza vaccine in children who have undergone allogeneic haematopoietic stem cell transplant

    Access Status
    Fulltext not available
    Authors
    Ryan, A.L.
    Wadia, U.D.
    Jacoby, P.
    Cheung, Laurence
    Kerr, F.
    Fraser, C.
    Tapp, H.
    Mechinaud, F.
    Carolan, L.A.
    Laurie, K.L.
    Barr, I.G.
    Blyth, C.C.
    Gottardo, N.G.
    Richmond, P.C.
    Kotecha, Rishi
    Date
    2020
    Type
    Journal Article
    
    Metadata
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    Citation
    Ryan, A.L. and Wadia, U.D. and Jacoby, P. and Cheung, L.C. and Kerr, F. and Fraser, C. and Tapp, H. et al. 2020. Immunogenicity of the inactivated influenza vaccine in children who have undergone allogeneic haematopoietic stem cell transplant. Bone Marrow Transplantation. 55 (4): pp. 773-779.
    Source Title
    Bone Marrow Transplantation
    DOI
    10.1038/s41409-019-0728-5
    ISSN
    0268-3369
    Faculty
    Faculty of Health Sciences
    School
    School of Pharmacy and Biomedical Sciences
    Funding and Sponsorship
    http://purl.org/au-research/grants/nhmrc/1142627
    http://purl.org/au-research/grants/nhmrc/1111596
    URI
    http://hdl.handle.net/20.500.11937/79266
    Collection
    • Curtin Research Publications
    Abstract

    © 2019, The Author(s), under exclusive licence to Springer Nature Limited. Influenza vaccination is recommended for children following allogeneic haematopoietic stem cell transplant (HSCT), however there is limited evidence regarding its benefit. A prospective multicentre study was conducted to evaluate the immunogenicity of the inactivated influenza vaccine in children who have undergone HSCT compared with healthy age-matched controls. Participants were vaccinated between 2013 and 2016 according to Australian guidelines. Influenza-specific hemagglutinin inhibition antibody titres were performed prior to each vaccination and 4 weeks following the final vaccination. A nasopharyngeal aspirate for influenza was performed on participants that developed influenza-like illness. There were 86 children recruited; 43 who had undergone HSCT and 43 controls. For the HSCT group, seroprotection and seroconversion rates were 81.4% and 60.5% for H3N2, 41.9% and 32.6% for H1N1, and 44.2% and 39.5% for B strain respectively. There was a significant geometric mean fold increase to the H3N2 (GMFI 5.80, 95% CI 3.68–9.14, p < 0.001) and B (GMFI 3.44, 95% CI 2.36–5.00, p = 0.048) strains. Serological response was superior in age-matched controls to all vaccine strains. There were no serious adverse events following vaccination. For children who underwent HSCT, incidence of laboratory-proven influenza infection was 2.3%. Overall, this study provides evidence to support annual inactivated influenza vaccine administration to children following HSCT.

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