Curtin University Homepage
  • Library
  • Help
    • Admin

    espace - Curtin’s institutional repository

    JavaScript is disabled for your browser. Some features of this site may not work without it.
    View Item 
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item

    The EXACT protocol: A multi-centre, single-blind, randomised, parallel-group, controlled trial to determine whether early oxygen titration improves survival to hospital discharge in adult OHCA patients

    Access Status
    Fulltext not available
    Authors
    Bray, Janet
    Smith, K.
    Hein, C.
    Finn, Judith
    Stephenson, M.
    Cameron, P.
    Stub, D.
    Perkins, G.D.
    Grantham, H.
    Bailey, P.
    Brink, D.
    Dodge, N.
    Bernard, S.
    Date
    2019
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Bray, J.E. and Smith, K. and Hein, C. and Finn, J. and Stephenson, M. and Cameron, P. and Stub, D. et al. 2019. The EXACT protocol: A multi-centre, single-blind, randomised, parallel-group, controlled trial to determine whether early oxygen titration improves survival to hospital discharge in adult OHCA patients. Resuscitation. 139: pp. 208-213.
    Source Title
    Resuscitation
    DOI
    10.1016/j.resuscitation.2019.04.023
    ISSN
    0300-9572
    Faculty
    Faculty of Health Sciences
    School
    School of Nursing, Midwifery and Paramedicine
    URI
    http://hdl.handle.net/20.500.11937/79488
    Collection
    • Curtin Research Publications
    Abstract

    Background: Experimental and observational research suggests hyperoxia following resuscitation from cardiac arrest is associated with neurological injury and worse clinical outcomes. This paper describes the rationale and design of the EXACT trial. EXACT aims to determine whether reducing oxygen in the acute phase of post-resuscitation care for out-of-hospital cardiac arrest (OHCA) improves survival. Methods: EXACT is a multi-centre, randomised (1:1), single-blind, parallel trial. Presumed cardiac OHCA cases who achieve a return of spontaneous circulation will be eligible if they are comatose, with an advanced airway and have an oxygen saturation (SpO2) ≥95% on >10 L/min (or 100% oxygen). Paramedics will randomise 1416 eligible cases to receive oxygen therapy targeting an SpO2 of 90–94% (intervention) or 98–100% (control). Study treatment will continue until admission to an intensive care unit or hospital ward. The primary outcome is survival to hospital discharge. Secondary outcomes include 12-month survival and quality of life. Results: The study has commenced in the Australian states of Victoria and South Australia, and has enrolled 167 eligible cases to date (80 intervention and 87 control). Further sites are due to commence in 2019, recruitment is expected to take three years. Conclusion: This study will determine if early reduction of oxygen leads to improved outcomes in OHCA. Such a finding may potentially change clinical practice with implications on future OHCA survival outcomes. Trial registration number: NCT03138005.

    Related items

    Showing items related by title, author, creator and subject.

    • Effect of Lower vs Higher Oxygen Saturation Targets on Survival to Hospital Discharge among Patients Resuscitated after Out-of-Hospital Cardiac Arrest: The EXACT Randomized Clinical Trial
      Bernard, S.A.; Bray, Janet ; Smith, K.; Stephenson, M.; Finn, Judith ; Grantham, H.; Hein, C.; Masters, S.; Stub, D.; Perkins, G.D.; Dodge, N.; Martin, C.; Hopkins, S.; Cameron, P. (2022)
      Importance: The administration of a high fraction of oxygen following return of spontaneous circulation in out-of-hospital cardiac arrest may increase reperfusion brain injury. Objective: To determine whether targeting a ...
    • Hospital characteristics are associated with patient outcomes following out- of-hospital cardiac arrest
      Stub, D.; Smith, K.; Bray, Janet; Bernard, S.; Duffy, S.; Kaye, D. (2011)
      Objective: Post-resuscitation care may influence outcome following transport to hospital after resuscitation from out-of-hospital cardiac arrest (OHCA). This study aimed to determine whether receiving hospital characteristics ...
    • Resuscitation of out-of-hospital cardiac arrests in residential aged care facilities in Melbourne, Australia
      Deasy, C.; Bray, Janet; Smith, K.; Harriss, L.; Bernard, S.; Davidson, P.; Cameron, P. (2012)
      Introduction: CPR in patients in residential aged care facilities (RACF) deserves careful consideration. We examined the characteristics, management and outcomes of out-of-hospital cardiac arrest (OHCA) in RACF patients ...
    Advanced search

    Browse

    Communities & CollectionsIssue DateAuthorTitleSubjectDocument TypeThis CollectionIssue DateAuthorTitleSubjectDocument Type

    My Account

    Admin

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Follow Curtin

    • 
    • 
    • 
    • 
    • 

    CRICOS Provider Code: 00301JABN: 99 143 842 569TEQSA: PRV12158

    Copyright | Disclaimer | Privacy statement | Accessibility

    Curtin would like to pay respect to the Aboriginal and Torres Strait Islander members of our community by acknowledging the traditional owners of the land on which the Perth campus is located, the Whadjuk people of the Nyungar Nation; and on our Kalgoorlie campus, the Wongutha people of the North-Eastern Goldfields.