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    Interhemispheric somatosensory differences in chronic pain reflect abnormality of the Healthy side

    Access Status
    Fulltext not available
    Authors
    Harrington, Flavia
    Stanton, T.R.
    Moseley, G.L.
    Lotze, M.
    Mcauley, J.H.
    Date
    2015
    Type
    Journal Article
    
    Metadata
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    Citation
    Di Pietro, F. and Stanton, T.R. and Moseley, G.L. and Lotze, M. and Mcauley, J.H. 2015. Interhemispheric somatosensory differences in chronic pain reflect abnormality of the Healthy side. Human Brain Mapping. 36 (2): pp. 508-518.
    Source Title
    Human Brain Mapping
    DOI
    10.1002/hbm.22643
    ISSN
    1065-9471
    Faculty
    Faculty of Health Sciences
    School
    School of Pharmacy and Biomedical Sciences
    Funding and Sponsorship
    http://purl.org/au-research/grants/nhmrc/630431
    http://purl.org/au-research/grants/nhmrc/1054041
    http://purl.org/au-research/grants/nhmrc/1061279
    URI
    http://hdl.handle.net/20.500.11937/79566
    Collection
    • Curtin Research Publications
    Abstract

    © 2014 Wiley Periodicals, Inc. It is widely accepted that complex regional pain syndrome (CRPS) is associated with shrinkage of the primary somatosensory cortex (S1) representation of the affected limb. However, supporting evidence is surprisingly limited and may be compromised by high risk of bias. This study compared the S1 spatial representation of the hand in 17 patients with upper-limb CRPS to 16 healthy controls, using functional MRI. Innocuous vibration was delivered to digits one (D1) and five (D5) in a block-design. Resultant activation maxima were located within a bilateral S1 mask, determined a priori. Distance between D1 and D5 activation maxima, calculated for both hands, was used as a measure of S1 representation. Analyses were blinded to group and hand. In patients, S1 representation was smaller for the affected hand than it was for the healthy hand (t(11)=2.02, P=0.03), as predicted. However, S1 representation of the affected hand was no different to that of either hand in controls. Critically, S1 representation of the healthy hand of patients was larger than that of controls' hands. CRPS seems to be associated with an enlarged representation of the healthy hand, not a smaller representation of the affected hand. These findings raise important questions about neuroplasticity in CRPS.

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