How do neuroanatomical changes in individuals with chronic pain result in the constant perception of pain?
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Since the advent of anatomical brain imaging analysis techniques, numerous reports have shown altered regional brain anatomy in individuals with various chronic pain conditions. While early reports of increased regional brain volumes in taxi drivers and pianists were simply interpreted as responses to excessive use, the mechanisms responsible for anatomical changes associated with chronic pain are not so straightforward. The main aim of this paper is to explore the potential underlying cellular changes responsible for change in gross brain anatomy in individuals with chronic pain, in particular pain following nervous system damage. Determining the basis of these changes may provide a platform for development of targeted, personalized and ultimately more effective treatment regimens.
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Mills, E.P.; Harrington, Flavia ; Alshelh, Z.; Peck, C.C.; Murray, G.M.; Vickers, E.R.; Henderson, L.A. (2018)© 2018 the authors. Preclinical investigations have suggested that altered functioning of brainstem pain-modulation circuits may be crucial for the maintenance of some chronic pain conditions. While some human psychophysical ...
Alshelh, Z.; Harrington, Flavia ; Mills, E.P.; Vickers, E.R.; Peck, C.C.; Murray, G.M.; Henderson, L.A. (2018)© 2018 The neural mechanisms underlying the development and maintenance of chronic pain following nerve injury remain unclear. There is growing evidence that chronic neuropathic pain is associated with altered thalamic ...
Motor control during an active straight leg raise in pain free and chronic pelvic girdle pain subjectsBeales, Darren (2009)Aberrant motor control strategies have been identified in chronic pelvic girdle pain (PGP) subjects. It has been proposed that aberrant motor control strategies could provide a mechanism for ongoing pain and disability ...