Preclinical efficacy of gemcitabine in MLL-rearranged infant acute lymphoblastic leukemia
| dc.contributor.author | Wander, P. | |
| dc.contributor.author | Cheung, Laurence | |
| dc.contributor.author | Pinhanҫos, S.S. | |
| dc.contributor.author | Jones, L. | |
| dc.contributor.author | Kerstjens, M. | |
| dc.contributor.author | Arentsen-Peters, S.T.C.J.M. | |
| dc.contributor.author | Singh, S. | |
| dc.contributor.author | Chua, G.A. | |
| dc.contributor.author | Castro, P.G. | |
| dc.contributor.author | Schneider, P. | |
| dc.contributor.author | Dolman, M.E.M. | |
| dc.contributor.author | Koopmans, B. | |
| dc.contributor.author | Molenaar, J.J. | |
| dc.contributor.author | Pieters, R. | |
| dc.contributor.author | Zwaan, C.M. | |
| dc.contributor.author | Kotecha, Rishi | |
| dc.contributor.author | Stam, R.W. | |
| dc.date.accessioned | 2020-06-09T23:41:32Z | |
| dc.date.available | 2020-06-09T23:41:32Z | |
| dc.date.issued | 2020 | |
| dc.identifier.citation | Wander, P. and Cheung, L.C. and Pinhanҫos, S.S. and Jones, L. and Kerstjens, M. and Arentsen-Peters, S.T.C.J.M. and Singh, S. et al. 2020. Preclinical efficacy of gemcitabine in MLL-rearranged infant acute lymphoblastic leukemia. Leukemia. | |
| dc.identifier.uri | http://hdl.handle.net/20.500.11937/79575 | |
| dc.identifier.doi | 10.1038/s41375-020-0895-9 | |
| dc.description.abstract |
The treatment of children diagnosed with acute lymphoblastic leukemia (ALL) has improved significantly over recent decades, with 5-year event-free survival (EFS) approaching 85% [1]. However, 5-year EFS for infants diagnosed at less than 1 year of age with MLL-rearranged ALL remains less than 40% [2]. MLL-rearranged infant ALL is both clinically and biologically distinct from other childhood ALL subtypes, which is reflected by a unique gene expression profile [3], a remarkably silent mutational landscape [4], and pronounced resistance to currently applied chemotherapeutics [5]. | |
| dc.language | eng | |
| dc.title | Preclinical efficacy of gemcitabine in MLL-rearranged infant acute lymphoblastic leukemia | |
| dc.type | Journal Article | |
| dcterms.source.issn | 0887-6924 | |
| dcterms.source.title | Leukemia | |
| dc.date.updated | 2020-06-09T23:41:31Z | |
| curtin.department | School of Pharmacy and Biomedical Sciences | |
| curtin.accessStatus | Fulltext not available | |
| curtin.faculty | Faculty of Health Sciences | |
| curtin.contributor.orcid | Kotecha, Rishi [0000-0003-1836-4075] | |
| curtin.contributor.orcid | Cheung, Laurence [0000-0001-6298-5288] | |
| dcterms.source.eissn | 1476-5551 | |
| curtin.contributor.scopusauthorid | Cheung, Laurence [56663936300] |