Inflammatory bowel disease: clinical aspects and treatments
MetadataShow full item record
Inflammatory bowel disease (IBD) is defined as a chronic intestinal inflammation that results from host-microbial interactions in a genetically susceptible individual. IBDs are a group of autoimmune diseases that are characterized by inflammation of both the small and large intestine, in which elements of the digestive system are attacked by the body's own immune system. This inflammatory condition encompasses two major forms, known as Crohn's disease and ulcerative colitis. Patients affected by these diseases experience abdominal symptoms, including diarrhea, abdominal pain, bloody stools, and vomiting. Moreover, defects in intestinal epithelial barrier function have been observed in a number of patients affected by IBD. In this review, we first describe the types and symptoms of IBD and investigate the role that the epithelial barrier plays in the pathophysiology of IBD as well as the major cytokines involved. We then discuss steps used to diagnose this disease and the treatment options available, and finally provide an overview of the recent research that aims to develop new therapies for such chronic disorders.
This open access article is distributed under the Creative Commons license http://creativecommons.org/licenses/by-nc-3.0/
Showing items related by title, author, creator and subject.
TNF block haplotypes reveal diverse pathways between TNF and disease: Implications for understanding neuropathy in HIV patientsChew, C.; Valente, F.; Wallace, H.; Tan, J.; Temple, S.; Price, Patricia (2012)The region spanning the tumor necrosis factor (TNF) cluster in the human major histocompatibility complex (MHC) has been implicated in susceptibility to numerous immunopathological and inflammatory diseases. However, ...
Modelling the co-occurence of Streptococcus pneumoniae with other bacterial and viral pathogens in the upper respiratory tractJacoby, P.; Watson, K.; Bowman, J.; Taylor, A.; Riley, T.; Smith, D.; Lehmann, Deborah (2007)Go to ScienceDirect® Home Skip Main Navigation Links Brought to you by: The University of Western Australia Library Login: + Register Athens/Institution Login Not Registered? - User Name: Password: ...
Inflammatory markers and extent and progression of early atherosclerosis: Meta-analysis of individual-participant-data from 20 prospective studies of the PROG-IMT collaborationWilleit, P.; Thompson, S.; Agewall, S.; Bergström, G.; Bickel, H.; Catapano, A.; Chien, K.; De Groot, E.; Empana, J.; Etgen, T.; Franco, O.; Iglseder, B.; Johnsen, S.; Kavousi, M.; Lind, L.; Liu, J.; Mathiesen, E.; Norata, Giuseppe; Olsen, M.; Papagianni, A.; Poppert, H.; Price, J.; Sacco, R.; Yanez, D.; Zhao, D.; Schminke, U.; Bülbül, A.; Polak, J.; Sitzer, M.; Hofman, A.; Grigore, L.; Dörr, M.; Su, T.; Ducimetière, P.; Xie, W.; Ronkainen, K.; Kiechl, S.; Rundek, T.; Robertson, C.; Fagerberg, B.; Bokemark, L.; Steinmetz, H.; Ikram, M.; Völzke, H.; Lin, H.; Plichart, M.; Tuomainen, T.; Desvarieux, M.; McLachlan, S.; Schmidt, C.; Kauhanen, J.; Willeit, J.; Lorenz, M.; Sander, D. (2016)© 2014 European Society of Cardiology. Background Large-scale epidemiological evidence on the role of inflammation in early atherosclerosis, assessed by carotid ultrasound, is lacking. We aimed to quantify cross-sectional ...