Curtin University Homepage
  • Library
  • Help
    • Admin

    espace - Curtin’s institutional repository

    JavaScript is disabled for your browser. Some features of this site may not work without it.
    View Item 
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item

    Inflammatory bowel disease: clinical aspects and treatments

    225321_144706_jir-7-113.pdf (970.7Kb)
    Access Status
    Open access
    Authors
    Fakhoury, M.
    Negrulj, Rebecca
    Mooranian, Armin
    Al-Salami, Hani
    Date
    2014
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Fakhoury, M. and Negrulj, R. and Mooranian, A. and Al-Salami, H. 2014. Inflammatory bowel disease: clinical aspects and treatments. Journal of Inflammation Research. 7: pp. 113-120.
    Source Title
    Journal of Inflammation Research
    DOI
    10.2147/JIR.S65979
    ISSN
    1178-7031
    School
    School of Pharmacy
    Remarks

    This open access article is distributed under the Creative Commons license http://creativecommons.org/licenses/by-nc-3.0/

    URI
    http://hdl.handle.net/20.500.11937/7975
    Collection
    • Curtin Research Publications
    Abstract

    Inflammatory bowel disease (IBD) is defined as a chronic intestinal inflammation that results from host-microbial interactions in a genetically susceptible individual. IBDs are a group of autoimmune diseases that are characterized by inflammation of both the small and large intestine, in which elements of the digestive system are attacked by the body's own immune system. This inflammatory condition encompasses two major forms, known as Crohn's disease and ulcerative colitis. Patients affected by these diseases experience abdominal symptoms, including diarrhea, abdominal pain, bloody stools, and vomiting. Moreover, defects in intestinal epithelial barrier function have been observed in a number of patients affected by IBD. In this review, we first describe the types and symptoms of IBD and investigate the role that the epithelial barrier plays in the pathophysiology of IBD as well as the major cytokines involved. We then discuss steps used to diagnose this disease and the treatment options available, and finally provide an overview of the recent research that aims to develop new therapies for such chronic disorders.

    Related items

    Showing items related by title, author, creator and subject.

    • TNF block haplotypes reveal diverse pathways between TNF and disease: Implications for understanding neuropathy in HIV patients
      Chew, C.; Valente, F.; Wallace, H.; Tan, J.; Temple, S.; Price, Patricia (2012)
      The region spanning the tumor necrosis factor (TNF) cluster in the human major histocompatibility complex (MHC) has been implicated in susceptibility to numerous immunopathological and inflammatory diseases. However, ...
    • Inflammatory markers and extent and progression of early atherosclerosis: Meta-analysis of individual-participant-data from 20 prospective studies of the PROG-IMT collaboration
      Willeit, P.; Thompson, S.; Agewall, S.; Bergström, G.; Bickel, H.; Catapano, A.; Chien, K.; De Groot, E.; Empana, J.; Etgen, T.; Franco, O.; Iglseder, B.; Johnsen, S.; Kavousi, M.; Lind, L.; Liu, J.; Mathiesen, E.; Norata, Giuseppe; Olsen, M.; Papagianni, A.; Poppert, H.; Price, J.; Sacco, R.; Yanez, D.; Zhao, D.; Schminke, U.; Bülbül, A.; Polak, J.; Sitzer, M.; Hofman, A.; Grigore, L.; Dörr, M.; Su, T.; Ducimetière, P.; Xie, W.; Ronkainen, K.; Kiechl, S.; Rundek, T.; Robertson, C.; Fagerberg, B.; Bokemark, L.; Steinmetz, H.; Ikram, M.; Völzke, H.; Lin, H.; Plichart, M.; Tuomainen, T.; Desvarieux, M.; McLachlan, S.; Schmidt, C.; Kauhanen, J.; Willeit, J.; Lorenz, M.; Sander, D. (2016)
      © 2014 European Society of Cardiology. Background Large-scale epidemiological evidence on the role of inflammation in early atherosclerosis, assessed by carotid ultrasound, is lacking. We aimed to quantify cross-sectional ...
    • Nutritional and pharmacological regulation of cerebral capillary function
      Pallebage-Gamarallage, Menuka Madhavi Somapala (2012)
      Alzheimer’s disease (AD) is the most common cause of dementia pathologically characterised by neurovascular inflammation, extracellular proteinaceous deposits enriched in amyloid-β (Aβ) and formation of neurofibrillar ...
    Advanced search

    Browse

    Communities & CollectionsIssue DateAuthorTitleSubjectDocument TypeThis CollectionIssue DateAuthorTitleSubjectDocument Type

    My Account

    Admin

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Follow Curtin

    • 
    • 
    • 
    • 
    • 

    CRICOS Provider Code: 00301JABN: 99 143 842 569TEQSA: PRV12158

    Copyright | Disclaimer | Privacy statement | Accessibility

    Curtin would like to pay respect to the Aboriginal and Torres Strait Islander members of our community by acknowledging the traditional owners of the land on which the Perth campus is located, the Whadjuk people of the Nyungar Nation; and on our Kalgoorlie campus, the Wongutha people of the North-Eastern Goldfields.