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dc.contributor.authorMurali, Shashank
dc.contributor.authorVogrin, Sara
dc.contributor.authorNoaman, Samer
dc.contributor.authorDinh, Diem T
dc.contributor.authorBrennan, Angela L
dc.contributor.authorLefkovits, Jeffrey
dc.contributor.authorReid, Christopher
dc.contributor.authorCox, Nicholas
dc.contributor.authorChan, William
dc.date.accessioned2020-07-16T03:51:20Z
dc.date.available2020-07-16T03:51:20Z
dc.date.issued2020
dc.identifier.citationMurali, S. and Vogrin, S. and Noaman, S. and Dinh, D.T. and Brennan, A.L. and Lefkovits, J. and Reid, C.M. et al. 2020. Bleeding Severity in Percutaneous Coronary Intervention (PCI) and Its Impact on Short-Term Clinical Outcomes. Journal of Clinical Medicine. 9 (5): Article No. 1426.
dc.identifier.urihttp://hdl.handle.net/20.500.11937/80049
dc.identifier.doi10.3390/jcm9051426
dc.description.abstract

Bleeding severity in patients undergoing percutaneous coronary intervention (PCI), defined by the Bleeding Academic Research Consortium (BARC), portends adverse prognosis. We analysed data from 37,866 Australian patients undergoing PCI enrolled in the Victorian Cardiac Outcomes Registry (VCOR), and investigated the association between increasing BARC severity and in-hospital and 30-day major adverse cardiac and cerebrovascular events (MACCE) (a composite of mortality, myocardial infarction, stent thrombosis, target vessel revascularisation, or stroke). Independent predictors associated with major bleeding (BARC groups 3&5), and MACCE were also assessed. There was a stepwise increase in in-hospital and 30-day MACCE with greater severity of bleeding. Independent predictors of bleeding included female sex (Odds Ratio (OR) 1.34), age (OR 1.02), fibrinolytic therapy (OR 1.77), femoral access (OR 1.51), and ticagrelor (OR 1.42), all significant at the p < 0.001 level. Following adjustment of clinically important variables, BARC 3&5 bleeds (OR 4.37) were still predictive of cumulative in-hospital and 30-day MACCE. In conclusion, major bleeding is an uncommon but potentially fatal PCI complication and was independently associated with greater MACCE rates. Efforts to mitigate the occurrence of bleeding, including radial access and judicious use of potent antiplatelet therapies, may ameliorate the risk of short-term adverse clinical outcomes.

dc.languageEnglish
dc.publisherMDPI
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectScience & Technology
dc.subjectLife Sciences & Biomedicine
dc.subjectMedicine, General & Internal
dc.subjectGeneral & Internal Medicine
dc.subjectBleeding Academic Research Consortium (BARC)
dc.subjectbleeding
dc.subjectpercutaneous coronary intervention (PCI)
dc.subjectclinical outcomes
dc.subjectmajor adverse cardiac and cerebrovascular events (MACCE)
dc.subjectBLOOD-TRANSFUSION
dc.subjectFEMORAL ACCESS
dc.subjectARTERY-DISEASE
dc.subjectMORTALITY
dc.subjectPREDICTORS
dc.subjectMETAANALYSIS
dc.subjectASSOCIATION
dc.subjectGUIDELINES
dc.subjectANGIOPLASTY
dc.subjectCLOPIDOGREL
dc.titleBleeding Severity in Percutaneous Coronary Intervention (PCI) and Its Impact on Short-Term Clinical Outcomes
dc.typeJournal Article
dcterms.source.volume9
dcterms.source.number5
dcterms.source.issn2077-0383
dcterms.source.titleJournal of Clinical Medicine
dc.date.updated2020-07-16T03:51:19Z
curtin.note

Published by MDPI Publishing.

curtin.departmentSchool of Public Health
curtin.accessStatusOpen access
curtin.facultyFaculty of Health Sciences
curtin.contributor.orcidReid, Christopher [0000-0001-9173-3944]
curtin.identifier.article-numberARTN 1426
dcterms.source.eissn2077-0383


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