Characterisation of Insulin at the Interface Between Two Immiscible Electrolyte Solutions
MetadataShow full item record
The behaviour of insulin was characterised at the interface between the two immiscible electrolyte solutions (ITIES). Electroadsorbed insulin was subjected to study by Fourier transform infrared and Raman spectroscopy, to understand any secondary structure changes following electroadsorption. Following electroadsorption, insulin showed secondary structure changes which varied with the aqueous insulin concentration. At higher concentration, significant proportions of combined ß-sheet and irregular helix structures were found, while a-helical forms were dominant at lower concentration. Raman spectroscopy was insensitive to insulin following electroadsorption.
Showing items related by title, author, creator and subject.
Deleo, Domenica (1994)Prior to the commencement of this study in 1990, a number of reports had appeared in the literature describing the importance of insulin action during lactation in mammals (see Chapter 1). These studies investigated the ...
Jin, X.; Zeng, L.; Zhang, S.; He, S.; Ren, Y.; Chen, Younan; Wei, L.; Wang, L.; Li, H.; Cheng, J.; Lu, Y. (2013)Monkeys with insulin-dependent diabetes are important preclinical animal models for islet transplantation. Exogenous insulin should be administered to achieve good glycemic control and minimize the long-term vascular ...
Xie, Ling; Helmerhorst, Erik; Plewright, Brian; Van Bronswijk, Wilhelm; Martins, R. (2002)The amyloid- (A) peptide is neurotoxic and associated with the pathology of Alzheimer's disease (AD). We investigated the effect of A peptides on insulin binding to the insulin receptor because it is known that (1) A and ...