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    Characterisation of Insulin at the Interface Between Two Immiscible Electrolyte Solutions

    Lamichhane H 2019.pdf (2.402Mb)
    Access Status
    Open access
    Authors
    Lamichhane, Hum Bahadur
    Date
    2019
    Supervisor
    Damien Arrigan
    Mark Hackett
    Type
    Thesis
    Award
    MPhil
    
    Metadata
    Show full item record
    Faculty
    Science and Engineering
    School
    School of Molecular and Life Sciences
    URI
    http://hdl.handle.net/20.500.11937/80108
    Collection
    • Curtin Theses
    Abstract

    The behaviour of insulin was characterised at the interface between the two immiscible electrolyte solutions (ITIES). Electroadsorbed insulin was subjected to study by Fourier transform infrared and Raman spectroscopy, to understand any secondary structure changes following electroadsorption. Following electroadsorption, insulin showed secondary structure changes which varied with the aqueous insulin concentration. At higher concentration, significant proportions of combined ß-sheet and irregular helix structures were found, while a-helical forms were dominant at lower concentration. Raman spectroscopy was insensitive to insulin following electroadsorption.

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